Evidence map›Paper›PMID 35323177›Full record

ArticleHematology reports2022

Challenges in Diagnosis and Clinical Management of COVID-19 in Patient with B-Cell Chronic Lymphocytic Leukemia (CLL): Report of One Case.

Vincenzo Visco, Maria Enrichetta Lippi, Gerardo Salerno, Maria Angela Vittoria A C Licata, Chiara de Dominicis, Giusy Antolino, Giacinto La Verde, Iolanda Santino, Maurizio Simmaco, Salvatore Sciacchitano

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In one paragraph

Article in Hematology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Vincenzo ViscoDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, "Sapienza" University of Rome, 00185 Rome, Italy.ORCID 0000-0001-5067-3121
Maria Enrichetta LippiDepartment of Cardiological Rehabilitation, IRCCS San Raffaele, 00163 Rome, Italy.
Gerardo SalernoDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, "Sapienza" University of Rome, 00185 Rome, Italy.ORCID 0000-0002-6597-1452
Maria Angela Vittoria A C LicataPulmonary Diseases Unit, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, 00168 Rome, Italy.
Chiara de DominicisDepartment of Surgical and Medical Sciences and Translational Medicine, "Sapienza" University of Rome, 00185 Rome, Italy.
Giusy AntolinoDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, "Sapienza" University of Rome, 00185 Rome, Italy.
Giacinto La VerdeDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, "Sapienza" University of Rome, 00185 Rome, Italy.
Iolanda SantinoDepartment of Clinical and Molecular Medicine, Sant'Andrea University Hospital, 00189 Rome, Italy.
Maurizio SimmacoDepartment of Clinical and Molecular Medicine, Sant'Andrea University Hospital, 00189 Rome, Italy.
Salvatore SciacchitanoDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, "Sapienza" University of Rome, 00185 Rome, Italy.
Sapienza University of Rome · ITAgostino Gemelli University Polyclinic · ITIRCCS Ospedale San Raffaele · ITUniversity Niccolò Cusano · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report here a case of a patient affected by B-cell chronic lymphocytic leukemia (CLL) that developed COVID-19 during the actual SARS-CoV-2 outbreak. The coexistence of CLL and COVID-19 raises many questions regarding the possible increased risk of developing COVID-19 among patients with CLL, the problems in managing therapies for both diseases and, above all, the difficulties in diagnosing COVID-19 in patients affected by CLL. In our patient, an 84-year-old man, the recognition of COVID-19 was delayed because of its atypical clinical presentation and technical problems related to the methods used for the diagnosis. Based on the symptoms and the radiological aspect of the lung, the occurrence of COVID-19 was suspected. Repeated tests on oro/nasopharyngeal swabs gave negative results, causing a delay in the diagnosis. Moreover, different methods used to identify the SARS-CoV-2 antibodies in serum gave conflicting results, and only two tests were able to identify SARS-CoV-2 Abs of the IgG type. During the clinical course of unrecognized COVID-19, our patient developed severe complications and did not receive any specific treatment for the two diseases. Recognition of COVID-19 in patients with CLL is a challenging task and the most accurate methods are necessary to overcome the diagnostic difficulties encountered.

Indexed as

antibodiesCLLCLL infectionmolecular diagnosisvirology

Identifiers

PMID35323177
PMCPMC8950198
OpenAlexW4221054967

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.