Trial reportmBio2022
Comparison of the Respiratory Resistomes and Microbiota in Children Receiving Short versus Standard Course Treatment for Community-Acquired Pneumonia.
Open access · goldAbstract readRandomized Controlled Trial
In one paragraph
Trial report in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
7.6field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Short- versus long-course antibiotic therapy in non-severe CAP in children: a systematic review and meta-analysis.European journal of pediatrics · 2026Pooled it
- Shorter Versus Longer Antibiotic Treatment in Children With Community-Acquired Pneumonia: A Systematic Review With Meta-Analyses.Deutsches Arzteblatt international · 2026Pooled it
- The respiratory microbiome influences the occurrence of respiratory diseases in children.Frontiers in pediatrics · 2026Review
- The Respiratory Tract Microbiome and Human Health.Microbial biotechnology · 2025Review
- Article
- Comprehensive human respiratory genome catalogue underlies the high resolution and precision of the respiratory microbiome.Briefings in bioinformatics · 2024Article
- Durations of Antibiotic Treatment for Acute Otitis Media and Variability in Prescribed Durations Across Two Large Academic Health Systems.Journal of the Pediatric Infectious Diseases Society · 2024Article
- Vitamin D ImprovesInfection and drug resistance · 2024Article
- Differential airway resistome and its correlations with clinical characteristics in Haemophilus- or Pseudomonas-predominant microbial subtypes of bronchiectasis.Respiratory research · 2023Article
- Priorities and Progress in Gram-positive Bacterial Infection Research by the Antibacterial Resistance Leadership Group: A Narrative Review.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Review
- The Antibacterial Resistance Leadership Group: Scientific Advancements and Future Directions.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- A Pipeline for Constructing Reference Genomes for Large Cohort-Specific Metagenome Compression.Microorganisms · 2023Article
- Effects of penicillin V on the faecal microbiota in patients with pharyngotonsillitis-an observational study.JAC-antimicrobial resistance · 2023Article
- Short-term antibiotic therapy for the most common bacterial respiratory infections in infants and children.Frontiers in pharmacology · 2023Review
- The Microbial Etiology of Community-Acquired Pneumonia in Adults: from Classical Bacteriology to Host Transcriptional Signatures.Clinical microbiology reviews · 2022Review
- Multidisciplinary Collaboration for the Optimization of Antibiotic Prescription: Analysis of Clinical Cases of Pneumonia between Emergency, Internal Medicine, and Pharmacy Services.Antibiotics (Basel, Switzerland) · 2022Article
- Intravenous antibiotic duration in the treatment of prosthetic joint infection: systematic review and meta-analysis.Journal of bone and joint infection · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 12 institutions in 1 country.
M M PettigrewDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, USA.ORCID 0000-0001-8145-7536
J KwonDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, USA.
J F GentDepartment of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut, USA.
Y KongDepartment of Biostatistics, Yale School of Public Health, New Haven, Connecticut, USA.
M WadeDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, USA.
D J WilliamsDepartment of Pediatrics and the Vanderbilt Vaccine Research Program, Vanderbilt University School of Medicinegrid.471397.f, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee, USA.
C B CreechDepartment of Pediatrics and the Vanderbilt Vaccine Research Program, Vanderbilt University School of Medicinegrid.471397.f, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee, USA.
S EvansBiostatistics Center, Milken Institute School of Public Health, George Washington Universitygrid.253615.6, Washington, DC, USA.
Q PanBiostatistics Center, Milken Institute School of Public Health, George Washington Universitygrid.253615.6, Washington, DC, USA.
E B WalterDepartment of Pediatrics, Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, USA.
J M MartinDepartment of Pediatrics, University of Pittsburgh School of Medicine, the UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-9456-1770
J S GerberChildren's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
J G NewlandDepartment of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
M E HoftoDepartment of Pediatrics, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA.
M A StaatCincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
V G FowlerDepartment of Medicine and Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA.
H F ChambersDepartment of Medicine, University of California San Francisco, San Francisco, California, USA.
W C HuskinsMayo Clinic College of Medicine and Science and the Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Antibacterial Resistance Leadership Group
Yale University · USDuke University · USMilken Institute · USMonroe Carell Jr. Children's Hospital · USChildren's Hospital of Philadelphia · USCincinnati Children's Hospital Medical Center · USMayo Clinic · USUniversity of Alabama at Birmingham · USUniversity of California, San Francisco · USUniversity of Pittsburgh · USWashington University in St. Louis · USW. M. Keck Foundation · US
Funding
Antibacterial Resistance Leadership Group (ARLG)UM1AI104681 · NIAID · DUKE UNIVERSITY · PI Vance G. Fowler, Henry F HENRY CHAMBERS · 2013 to 2026
$180.8MYale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MNCATS NIH HHS UL1 TR001863NIAID NIH HHS UM1 AI104681
Abstract
Pediatric community-acquired pneumonia (CAP) is often treated with 10 days of antibiotics. Shorter treatment strategies may be effective and lead to less resistance. The impact of duration of treatment on the respiratory microbiome is unknown. Data are from children (
Indexed as
Community-Acquired InfectionsMicrobiotaPneumoniaAnti-Bacterial Agentsbeta-LactamsChildChild, PreschoolHumansInfantAnti-Bacterial Agentsbeta-Lactamsantibiotic resistancechildrencommunity-acquired pneumoniamicrobiotaresistomerespiratory tract infections
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.