Evidence map›Paper›PMID 35323039›Full record

ArticlemBio2022

Role of MUC5B during Group B Streptococcal Vaginal Colonization.

Lindsey R Burcham, Jade R Bath, Caroline A Werlang, Laurie M Lyon, Naoko Liu, Christopher Evans, Katharina Ribbeck, Kelly S Doran

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Review
  3. mBio · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Adhesion of Pseudomonas aeruginosa to Human Outer Layer Airway Mucins.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  8. Re-framing the importance of Group BInfection and immunity · 2024
    Review
  9. Article
  10. Mucin Glycans: A Target for Cancer Therapy.Molecules (Basel, Switzerland) · 2023
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Lindsey R BurchamDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Jade R Bath *Department of Biological Engineering, Massachusetts Institute of Technologygrid.116068.8, Cambridge, Massachusetts, USA.
Caroline A Werlang *Department of Biological Engineering, Massachusetts Institute of Technologygrid.116068.8, Cambridge, Massachusetts, USA.
Laurie M LyonDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Naoko LiuDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.
Christopher EvansDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.
Katharina RibbeckDepartment of Biological Engineering, Massachusetts Institute of Technologygrid.116068.8, Cambridge, Massachusetts, USA.
Kelly S DoranDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.ORCID 0000-0003-4232-6837
University of Colorado Denver · USMassachusetts Institute of Technology · US

Funding

TRAINING GRANTS IN ENVIROMENTAL TOXICOLOGYT32ES007020 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ESSIGMANN, JOHN M · 1985 to 2024
$13.1M
Role of Mucin in Lung Homeostasis and PathophysiologyR01HL080396 · NHLBI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Christopher M Evans · 2009 to 2026
$8.6M
Mechanisms of lung macrophage programming by MUC5B during health and diseaseR01HL130938 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI EVANS, CHRISTOPHER M · 2016 to 2025
$5.2M
Mucin Glycans in the Regulation of Microbial VirulenceR01EB017755 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI RIBBECK, KATHARINA · 2013 to 2022
$3.6M
Host and bacterial mechanisms governing Group B streptococcal persistence in the female genital tractR01AI153332 · NIAID · UNIVERSITY OF COLORADO DENVER · PI DORAN, KELLY S · 2021 to 2025
$2.9M
Molecular Pathogenesis of Infectious DiseasesT32AI052066 · NIAID · UNIVERSITY OF COLORADO DENVER · PI VAN DYK, LINDA F. · 2002 to 2022
$2.3M
Modulation of Blood-Brain Barrier Defense and Dysfunction during Bacterial MeningitisR01NS116716 · NINDS · UNIVERSITY OF COLORADO DENVER · PI DORAN, KELLY S · 2020 to 2024
$1.9M
NHLBI NIH HHS R01 HL080396NHLBI NIH HHS R01 HL130938NIAID NIH HHS R01 AI153332NIAID NIH HHS T32 AI052066NIBIB NIH HHS R01 EB017755NIEHS NIH HHS T32 ES007020NINDS NIH HHS R01 NS116716
6 · The paper itself

Abstract

The female reproductive tract (FRT) is a complex environment, rich in mucin glycoproteins that form a dense network on the surface of the underlying epithelia. Group B Streptococcus (GBS) asymptomatically colonizes 25-30% of healthy women, but during pregnancy can cause ascending infection

Indexed as

Premature BirthStreptococcal InfectionsAnimalsFemaleHumansInfant, NewbornMiceMucin-5BMucinsPregnancyStreptococcus agalactiaeVaginaMUC5B protein, humanMuc5b protein, mouseMucin-5BMucinsmucinpilivaginal colonization

Identifiers

PMID35323039
PMCPMC9040740
OpenAlexW4221053545

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.