Evidence map›Paper›PMID 35322680›Full record

ArticleJournal of the American Heart Association2022

Risk Factors, Subsequent Disease Onset, and Prognostic Impact of Myocardial Infarction and Atrial Fibrillation.

Stephan Camen, Dora Csengeri, Bastiaan Geelhoed, Teemu Niiranen, Francesco Gianfagna, Julie K Vishram-Nielsen, Simona Costanzo, Stefan Söderberg, Erkki Vartiainen, Christin S Börschel and 18 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Observational
  8. Practical guide on left atrial appendage closure for the non-implanting physician: an international consensus paper.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
  9. Review
  10. Discovery ofBiology · 2023
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 12 institutions in 8 countries.

Stephan CamenDepartment of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf Hamburg Germany.ORCID 0000-0003-0224-9208
Dora CsengeriDepartment of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf Hamburg Germany.ORCID 0000-0002-6210-349X
Bastiaan GeelhoedDepartment of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf Hamburg Germany.
Teemu NiiranenFinnish Institute for Health and Welfare Helsinki Finland.ORCID 0000-0002-7394-7487
Francesco GianfagnaResearch Center in Epidemiology and Preventive Medicine Department of Medicine and Surgery University of Insubria Varese Italy.ORCID 0000-0003-4615-0816
Julie K Vishram-NielsenCenter for Clinical Research and Prevention Bispebjerg and Frederiksberg HospitalThe Capital Region of Denmark Copenhagen Denmark.ORCID 0000-0003-1762-7750
Simona CostanzoDepartment of Epidemiology and Prevention Istituto Neurologico Mediterraneo è un Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Neuromed Pozzilli Italy.ORCID 0000-0003-4569-1186
Stefan SöderbergDepartment of Public Health and Clinical Medicine, and Heart Centre Umeå University Umeå Sweden.ORCID 0000-0001-9225-1306
Erkki VartiainenFinnish Institute for Health and Welfare Helsinki Finland.ORCID 0000-0001-7498-4389
Christin S BörschelDepartment of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf Hamburg Germany.
Maria Benedetta DonatiDepartment of Epidemiology and Prevention Istituto Neurologico Mediterraneo è un Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Neuromed Pozzilli Italy.ORCID 0000-0003-1747-5443
Maja-Lisa LøchenDepartment of Community Medicine UiT The Arctic University of Norway Tromsø Norway.ORCID 0000-0002-8532-6573
Francisco M OjedaDepartment of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf Hamburg Germany.
Jukka KonttoFinnish Institute for Health and Welfare Helsinki Finland.ORCID 0000-0003-3899-9852
Ellisiv B MathiesenBrain and Circulation Research Group Department of Clinical Medicine UiT The Arctic University of Norway Tromsø Norway.ORCID 0000-0001-8887-6100
Steen JensenDepartment of Public Health and Clinical Medicine, and Heart Centre Umeå University Umeå Sweden.
Wolfgang KoenigGerman Heart Center MunichTechnical University of Munich Munich Germany.ORCID 0000-0002-2064-9603
Frank KeeCentre for Public Health, Queens University of Belfast Belfast UK.
Giovanni de GaetanoDepartment of Epidemiology and Prevention Istituto Neurologico Mediterraneo è un Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Neuromed Pozzilli Italy.ORCID 0000-0002-7823-1402
Tanja ZellerDepartment of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf Hamburg Germany.
Torben JørgensenCenter for Clinical Research and Prevention Bispebjerg and Frederiksberg HospitalThe Capital Region of Denmark Copenhagen Denmark.ORCID 0000-0001-9453-2830
Hugh Tunstall-PedoeCardiovascular Epidemiology Unit Institute of Cardiovascular ResearchUniversity of Dundee Dundee UK.
Stefan BlankenbergDepartment of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf Hamburg Germany.
Kari KuulasmaaFinnish Institute for Health and Welfare Helsinki Finland.ORCID 0000-0003-2165-1411
Allan LinnebergCenter for Clinical Research and Prevention Bispebjerg and Frederiksberg HospitalThe Capital Region of Denmark Copenhagen Denmark.
Veikko SalomaaFinnish Institute for Health and Welfare Helsinki Finland.ORCID 0000-0001-7563-5324
Licia IacovielloResearch Center in Epidemiology and Preventive Medicine Department of Medicine and Surgery University of Insubria Varese Italy.ORCID 0000-0003-0514-5885
Renate B SchnabelDepartment of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf Hamburg Germany.ORCID 0000-0001-7170-9509
Universität Hamburg · DEFinnish Institute for Health and Welfare · FIIstituto Neurologico Mediterraneo · ITUniversity of Copenhagen · DKUmeå University · SEUniversity of Insubria · ITQueens University · BDUiT The Arctic University of Norway · NOUniversität Ulm · DEUniversity Hospital of North Norway · NOUniversity of Dundee · GBUniversity of Turku · FI

Funding

Medical Research Council G0601463Medical Research Council MR/K023241/1
6 · The paper itself

Abstract

Background Although myocardial infarction (MI) and atrial fibrillation (AF) are frequent comorbidities and share common cardiovascular risk factors, the direction and strength of the association of the risk factors with disease onset, subsequent disease incidence, and mortality are not completely understood. Methods and Results In pooled multivariable Cox regression analyses, we examined temporal relations of disease onset and identified predictors of MI, AF, and all-cause mortality in 108 363 individuals (median age, 46.0 years; 48.2% men) free of MI and AF at baseline from 6 European population-based cohorts. During a maximum follow-up of 10.0 years, 3558 (3.3%) individuals were diagnosed exclusively with MI, 1922 (1.8%) with AF but no MI, and 491 (0.5%) individuals developed both MI and AF. Association of sex, systolic blood pressure, antihypertensive treatment, and diabetes appeared to be stronger with incident MI than with AF, whereas increasing age and body mass index showed a higher risk for incident AF. Total cholesterol and daily smoking were significantly related to incident MI but not AF. Combined population attributable fraction of cardiovascular risk factors was >70% for incident MI, whereas it was only 27% for AF. Subsequent MI after AF (hazard ratio [HR], 1.68; 95% CI, 1.03-2.74) and subsequent AF after MI (HR, 1.75; 95% CI, 1.31-2.34) both significantly increased overall mortality risk. Conclusions We observed different associations of cardiovascular risk factors with both diseases indicating distinct pathophysiological pathways. Subsequent diagnoses of MI and AF significantly increased mortality risk.

Indexed as

Atrial FibrillationMyocardial InfarctionFemaleHumansIncidenceMaleMiddle AgedPrognosisProportional Hazards ModelsRisk Factorsatrial fibrillationcohort studymortalitymyocardial infarctionrisk factors

Identifiers

PMID35322680
PMCPMC9075452
OpenAlexW4220659316

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.