SynthesisAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022
Material-Assisted Strategies for Osteochondral Defect Repair.
Synthesis in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- Mesenchymal stem cell-derived extracellular vesicles for osteochondral defect regeneration: a systematic review and meta-analysis of preclinical studies.Journal of translational medicine · 2026Pooled it
- The Statistical Fragility of Marrow Stimulation for Cartilage Defects of the Knee: A Systematic Review of Randomized Controlled Trials.Cartilage · 2024Pooled it
- Material-Assisted Strategies for Osteochondral Defect Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Pooled it
- Natural Biomaterials for Osteochondral Repair: From Source to Strategy.Advanced healthcare materials · 2026Review
- Multifunctional ultrafast hydrogel for arthroscopic surgery: An enzymatically cross-linked, nanosilicate-reinforced system promotes dual cartilage and subchondral bone regeneration.Journal of orthopaedic translation · 2026Article
- Biomaterial-assisted gene therapy for bone repair.Materials today. Bio · 2026Review
- Autologous Osteochondral Transplantation in Large Osteochondral Defects-A Follow-Up of 40 Patients After Talus Re-Surfacing.Diagnostics (Basel, Switzerland) · 2026Article
- Copper-ion releasing LDH nanosheets-hydrogel synergistically enhance subchondral bone repair.Regenerative biomaterials · 2026Article
- Three-dimensionally-printed biphasic PCL/Regenerative biomaterials · 2026Article
- NAT10 promotes osteoclastogenesis in inflammatory bone loss by catalyzing Fos mRNA ac4C modification and upregulating MAPK signaling pathway.Journal of advanced research · 2025Article
- Additive manufacturing of patient-specific, biphasic implants with zonal design for regeneration of osteochondral defects-critical evaluation of the work flow from clinical MRI data to implantation.Materials today. Bio · 2025Article
- Osteochondral tissue engineering‑based subchondral bone plate repair (Review).Molecular medicine reports · 2025Review
- In vitro and in vivo study of concentrated growth factor (CGF) mediating macrophage polarization in bone defect repair.Regenerative therapy · 2025Article
- Antioxidant scaffolds for enhanced bone regeneration: recent advances and challenges.Biomedical engineering online · 2025Review
- Tomographic Assessment of Bone Regeneration in Osteochondral Lesion Treated with Various Biomaterials in a Sheep Model Study.Journal of functional biomaterials · 2025Article
- Engineered Osteochondral Scaffolds with Bioactive Cartilage Zone for Enhanced Articular Cartilage Regeneration.Annals of biomedical engineering · 2025Article
- Local delivery of TGF-β1-mRNA decreases fibrosis in osteochondral defects.Bioactive materials · 2025Article
- Current Understanding and Translational Prospects of Tetrahedral Framework Nucleic Acids.JACS Au · 2025Review
- The impact of microstructure and extracellular matrix suspension on the proliferation of bone marrow-derived mesenchymal stem cells for osteochondral defect repair.Regenerative biomaterials · 2025Article
- Fabrication of collagen-based biomaterials for sports medicine application.Regenerative biomaterials · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The osteochondral (OC) unit plays a pivotal role in joint lubrication and in the transmission of constraints to bones during movement. The OC unit does not spontaneously heal; therefore, OC defects are considered to be one of the major risk factors for developing long-term degenerative joint diseases such as osteoarthritis. Yet, there is currently no curative treatment for OC defects, and OC regeneration remains an unmet medical challenge. In this context, a plethora of tissue engineering strategies have been envisioned over the last two decades, such as combining cells, biological molecules, and/or biomaterials, yet with little evidence of successful clinical transfer to date. This striking observation must be put into perspective with the difficulty in comparing studies to identify overall key elements for success. This systematic review aims to provide a deeper insight into the field of material-assisted strategies for OC regeneration, with particular considerations for the therapeutic potential of the different approaches (with or without cells or biological molecules), and current OC regeneration evaluation methods. After a brief description of the biological complexity of the OC unit, the recent literature is thoroughly analyzed, and the major pitfalls, emerging key elements, and new paths to success are identified and discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.