Evidence map›Paper›PMID 35322571›Full record

ArticleChemMedChem2022

Conjugates of Tacrine with Salicylamide as Promising Multitarget Agents for Alzheimer's Disease.

Maria V Grishchenko, Galina F Makhaeva, Yanina V Burgart, Elena V Rudakova, Natalia P Boltneva, Nadezhda V Kovaleva, Olga G Serebryakova, Sofya V Lushchekina, Tatiana Y Astakhova, Ekaterina F Zhilina and 3 more

Abstract read
In one paragraph

Article in ChemMedChem, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Maria V GrishchenkoPostovsky Institute of Organic Synthesis, Urals Branch of Russian Academy of Sciences, 620990, Ekaterinburg, Russia.ORCID 0000-0003-4110-2620
Galina F MakhaevaInstitute of Physiologically Active Compounds, Russian Academy of Sciences, 142432, Chernogolovka, Russia.ORCID 0000-0002-8136-6906
Yanina V BurgartPostovsky Institute of Organic Synthesis, Urals Branch of Russian Academy of Sciences, 620990, Ekaterinburg, Russia.ORCID 0000-0001-6061-2410
Elena V RudakovaInstitute of Physiologically Active Compounds, Russian Academy of Sciences, 142432, Chernogolovka, Russia.ORCID 0000-0002-4600-7799
Natalia P BoltnevaInstitute of Physiologically Active Compounds, Russian Academy of Sciences, 142432, Chernogolovka, Russia.ORCID 0000-0002-7171-8832
Nadezhda V KovalevaInstitute of Physiologically Active Compounds, Russian Academy of Sciences, 142432, Chernogolovka, Russia.ORCID 0000-0002-4990-5068
Olga G SerebryakovaInstitute of Physiologically Active Compounds, Russian Academy of Sciences, 142432, Chernogolovka, Russia.ORCID 0000-0002-0313-1423
Sofya V LushchekinaInstitute of Physiologically Active Compounds, Russian Academy of Sciences, 142432, Chernogolovka, Russia.ORCID 0000-0002-6922-020X
Tatiana Y AstakhovaEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334, Moscow, Russia.ORCID 0000-0002-3034-9698
Ekaterina F ZhilinaPostovsky Institute of Organic Synthesis, Urals Branch of Russian Academy of Sciences, 620990, Ekaterinburg, Russia.ORCID 0000-0002-1657-440X
Evgeny V ShchegolkovPostovsky Institute of Organic Synthesis, Urals Branch of Russian Academy of Sciences, 620990, Ekaterinburg, Russia.ORCID 0000-0001-6611-2855
Rudy J RichardsonDepartments of Environmental Health Sciences and Neurology, University of Michigan, 48109, Ann Arbor, MI, USA.ORCID 0000-0002-2028-5723
Victor I SaloutinPostovsky Institute of Organic Synthesis, Urals Branch of Russian Academy of Sciences, 620990, Ekaterinburg, Russia.ORCID 0000-0003-1976-7861

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

New conjugates of tacrine and salicylamide with alkylene spacers were synthesized and evaluated as potential multifunctional agents for Alzheimer's disease (AD). The compounds exhibited high acetylcholinesterase (AChE, IC

Indexed as

Alzheimer DiseaseNeuroprotective AgentsAcetylcholinesteraseAmyloid beta-PeptidesButyrylcholinesteraseCholinesterase InhibitorsHumansMolecular Docking SimulationSalicylamidesStructure-Activity RelationshipTacrineAcetylcholinesteraseAmyloid beta-PeptidesButyrylcholinesteraseCholinesterase InhibitorsNeuroprotective AgentsSalicylamidesTacrineanti-AD multifunctional agentscholinesterase inhibitorsmolecular dockingsalicylamideTacrine

Identifiers

PMID35322571
PMCPMC9314152

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.