Evidence map›Paper›PMID 35322566›Full record

ArticleJournal of diabetes2022

C3c deposition predicts worse renal outcomes in patients with biopsy-proven diabetic kidney disease in type 2 diabetes mellitus.

Meng-Rui Li, Zi-Jun Sun, Dong-Yuan Chang, Xiao-Juan Yu, Su-Xia Wang, Min Chen, Ming-Hui Zhao

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07292493 (The Role of Complement in Diabetic Kidney Disease), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07292493 enrolling by invitationnot on this mapstarted 2025, after this paper: background citation

The Role of Complement in Diabetic Kidney Disease

TypeobservationalSponsorUniversity Medical Centre LjubljanaRan2025 to 2028Enrolled90ConditionsDiabetes, Diabetic Kidney Disease, Complement System
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Complement anaphylatoxins: Potential therapeutic target for diabetic kidney disease.Diabetic medicine : a journal of the British Diabetic Association · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Meng-Rui LiRenal Division, Department of Medicine, Peking University First Hospital, Beijing, China.ORCID https://orcid.org/0000-0002-1194-5240
Zi-Jun SunRenal Division, Department of Medicine, Peking University First Hospital, Beijing, China.ORCID https://orcid.org/0000-0002-6664-5026
Dong-Yuan ChangRenal Division, Department of Medicine, Peking University First Hospital, Beijing, China.
Xiao-Juan YuRenal Division, Department of Medicine, Peking University First Hospital, Beijing, China.
Su-Xia WangRenal Division, Department of Medicine, Peking University First Hospital, Beijing, China.
Min ChenRenal Division, Department of Medicine, Peking University First Hospital, Beijing, China.
Ming-Hui ZhaoRenal Division, Department of Medicine, Peking University First Hospital, Beijing, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

CAMS Innovation Fund for Medical Sciences 2019-I2M-5-046China International Medical Foundation-Renal Anemia FundNational Key Research and Development Program 2016YFC1305405the National Natural Science Found 82070748the National Natural Science Found 82090020the National Natural Science Found 82090021
6 · The paper itself

Abstract

backgroundAlthough extensive efforts have been paid to identify reliable predictors for renal outcomes of diabetic kidney disease (DKD) patients in type 2 diabetes mellitus (T2DM), there are still only a limited number of predictive factors for DKD progression. Increasing evidence reported the role of the overactivated complement system in the pathogenesis of DKD. Whether renal complement depositions are associated with renal outcomes of DKD in T2DM is of interest.

methodsA total of 213 biopsy-proven DKD patients with T2DM were retrospectively recruited. Clinical and pathological data of the patients were analyzed. Kaplan-Meier analysis and Cox regression analysis were performed to explore predictors of end-stage renal disease (ESRD).

resultsDuring a median follow-up of 23.0 (12.0, 39.0) months, 100/213 (46.9%) patients progressed to ESRD. C3c and C1q deposition were observed in 133/213 (62.4%) and 45/213 (21.1%) patients, respectively. Kaplan-Meier analysis revealed patients with C3c or C1q deposition had significantly worse renal outcomes compared with those without C3c or C1q deposition (p = .001 and p < .001, respectively). Univariate and multivariate Cox regression analysis demonstrated proteinuria (per 1 g/24 h increase, hazard ratio [HR] 1.134, 95% confidence interval [CI] [1.079, 1.191], p < .001), interstitial fibrosis and tubular atrophy score (score 2 and 3 vs. 0 and 1, HR 3.925, 95% CI [1.855, 8.304], p < .001), and C3c deposition (per 1+ increase, HR 1.299, 95% CI [1.073, 1.573], p = .007) were independent predictors for ESRD in DKD patients with T2DM.

conclusionsC3c deposition in the kidney was associated with worse renal outcomes and was an independent predictor for ESRD in DKD patients with T2DM.

Indexed as

Diabetes Mellitus, Type 2Diabetic NephropathiesKidney Failure, ChronicBiopsyComplement C1qDisease ProgressionFemaleHumansKidneyMalePrognosisRetrospective StudiesComplement C1qC3complementdiabetic kidney diseaseprognosisrenal pathology糖尿病肾病肾脏病理补体预后

Identifiers

PMID35322566
PMCPMC9060041
OpenAlexW4221000190

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.