ArticleActa ophthalmologica2022
Automated artificial intelligence-based system for clinical follow-up of patients with age-related macular degeneration.
Article in Acta ophthalmologica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Fluid/function correlation using AI-based quantification versus central subfield thickness in treatment-naïve and pre-treated patients with neovascular AMD in a real-world setting.Acta ophthalmologica · 2026Trial
- Real-world evaluation of an OCT-based AI decision-support system for neovascular AMD activity triage in teleophthalmology.Frontiers in ophthalmology · 2026Article
- Managing Patient Demand in a Value-Based System.Annals of family medicine · 2025Article
- Between Surveillance and Support: A Qualitative Study of Tuberculosis Patients' Expectations and Concerns About AI-Assisted Remote Health Services in China.Patient preference and adherence · 2025Article
- Artificial intelligence in ophthalmology: The path to the real-world clinic.Cell reports. Medicine · 2023Review
- Prediction of anti-vascular endothelial growth factor agent-specific treatment outcomes in neovascular age-related macular degeneration using a generative adversarial network.Scientific reports · 2023Article
- Artificial intelligence-based pathologic myopia identification system in the ophthalmology residency training program.Frontiers in cell and developmental biology · 2022Article
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Authors and funding
8 authors.
Funding
Abstract
purposeIn this study, we investigate the potential of a novel artificial intelligence-based system for autonomous follow-up of patients treated for neovascular age-related macular degeneration (AMD).
methodsA temporal deep learning model was trained on a data set of 84 489 optical coherence tomography scans from AMD patients to recognize disease activity, and its performance was compared with a published non-temporal model trained on the same data (Acta Ophthalmol, 2021). An autonomous follow-up system was created by augmenting the AI model with deterministic logic to suggest treatment according to the observe-and-plan regimen. To validate the AI-based system, a data set comprising clinical decisions and imaging data from 200 follow-up consultations was collected prospectively. In each case, both the autonomous AI decision and original clinical decision were compared with an expert panel consensus.
resultsThe temporal AI model proved superior at detecting disease activity compared with the model without temporal input (area under the curve 0.900 (95% CI 0.894-0.906) and 0.857 (95% CI 0.846-0.867) respectively). The AI-based follow-up system could make an autonomous decision in 73% of the cases, 91.8% of which were in agreement with expert consensus. This was on par with the 87.7% agreement rate between decisions made in the clinic and expert consensus (p = 0.33).
conclusionsThe proposed autonomous follow-up system was shown to be safe and compliant with expert consensus on par with clinical practice. The system could in the future ease the pressure on public ophthalmology services from an increasing number of AMD patients.
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