ArticleBipolar disorders2022
Predictors of functional impairment in bipolar disorder: Results from 13 cohorts from seven countries by the global bipolar cohort collaborative.
Article in Bipolar disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 4 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Optimizing Treatment Strategies in the Bipolar Disorder Spectrum With Classical AI Approaches: Systematic Review of Performance, Bias, and Clinical Applicability.JMIR mental health · 2026Pooled it
- Relationships between cognition and daily functioning in adults with bipolar disorder: A systematic review and multilevel meta-analysis.Psychological bulletin · 2026Pooled it
- Clinical impact of obsessive-compulsive disorder comorbidity in bipolar disorder: a systematic review and meta-analysis.European psychiatry : the journal of the Association of European Psychiatrists · 2025Pooled it
- Impact of cognitive reserve on bipolar disorder: a systematic review.Frontiers in psychiatry · 2023Pooled it
- Contraceptive use in women of childbearing age with bipolar disorder.BMC psychiatry · 2026Article
- Unipolar mania as a distinct clinical presentation: Differences in illness course and psychosocial functioning compared with bipolar I disorder.Dusunen adam : Bakirkoy Ruh ve Sinir Hastaliklari Hastanesi yayin organi · 2026Article
- Expanding Coordinated Specialty Care to Early-Stage Bipolar Disorder: Development and Implementation of the STRIDE Model.Early intervention in psychiatry · 2026Article
- The anxious bipolar phenotype: clinical complexity and treatment response.International journal of bipolar disorders · 2026Article
- Association Between Metabolic Syndrome, Obesity, and Cognitive Performances in Individuals With Bipolar Disorders: Cross-Sectional and Longitudinal Analyses in the FACE-BD Cohort.Acta psychiatrica Scandinavica · 2026Article
- Prevalence and correlates of social dysfunction in community-dwelling patients with bipolar disorder: a cross-sectional study.BMC psychiatry · 2026Article
- The Anxious Bipolar Phenotype: Clinical Complexity and Treatment Resistance.Research square · 2026Article
- Cognitive Symptoms and Overall Functioning During Major Depressive Episodes: Correlation Analysis of Patients With Unipolar and Bipolar Disorders.Depression and anxiety · 2026Observational
- The breakthrough discoveries for thriving with bipolar disorder (BDInternational journal of bipolar disorders · 2025Article
- Sex-specific associations of episode type in bipolar I disorder with neuro-metabolic lateralization of the cortico-striatal-cerebellar (CSC) circuit.BMC psychiatry · 2025Article
- Disease progression in bipolar disorder in relation to white matter microstructure: A comprehensive approach based on staging models.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Relationships between cognition and symptoms across mood and psychotic disorders.Psychiatry research · 2025Article
- Integrating Knowledge: The Power of Ontologies in Psychiatric Research and Clinical Informatics.Biological psychiatry · 2025Review
- Predominant Polarity for Enhanced Phenotyping and Personalized Treatment of Bipolar Disorder: A Narrative Review on Recent Findings.Current psychiatry reports · 2025Review
- Global Trends in the Use of Pharmacotherapy for the Treatment of Bipolar Disorder.Current psychiatry reports · 2025Review
- Lithium for depression-related hospitalisation in bipolar disorder.The lancet. Psychiatry · 2025Article
Corrections and comments
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Authors and funding
50 authors at 20 institutions in 8 countries.
Funding
Abstract
objectivesPersistent functional impairment is common in bipolar disorder (BD) and is influenced by a number of demographic, clinical, and cognitive features. The goal of this project was to estimate and compare the influence of key factors on community function in multiple cohorts of well-characterized samples of individuals with BD.
methodsThirteen cohorts from 7 countries included n = 5882 individuals with BD across multiple sites. The statistical approach consisted of a systematic uniform application of analyses across sites. Each site performed a logistic regression analysis with empirically derived "higher versus lower function" as the dependent variable and selected clinical and demographic variables as predictors.
resultsWe found high rates of functional impairment, ranging from 41 to 75%. Lower community functioning was associated with depressive symptoms in 10 of 12 of the cohorts that included this variable in the analysis. Lower levels of education, a greater number of prior mood episodes, the presence of a comorbid substance use disorder, and a greater total number of psychotropic medications were also associated with low functioning.
conclusionsThe bipolar clinical research community is poised to work together to characterize the multi-dimensional contributors to impairment and address the barriers that impede patients' complete recovery. We must also identify the core features which enable many to thrive and live successfully with BD. A large-scale, worldwide, prospective longitudinal study focused squarely on BD and its heterogeneous presentations will serve as a platform for discovery and promote major advances toward optimizing outcomes for every individual with this illness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.