Evidence map›Paper›PMID 35322455›Full record

ArticleStatistics in medicine2022

Tracking the transmission dynamics of COVID-19 with a time-varying coefficient state-space model.

Joshua P Keller, Tianjian Zhou, Andee Kaplan, G Brooke Anderson, Wen Zhou

Abstract read
In one paragraph

Article in Statistics in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Data assimilation for estimating time-varying reproduction numbers.Journal of the Royal Society, Interface · 2025
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Joshua P KellerDepartment of Statistics, Colorado State University, Fort Collins, Colorado, USA.ORCID 0000-0002-9423-2704
Tianjian ZhouDepartment of Statistics, Colorado State University, Fort Collins, Colorado, USA.ORCID 0000-0002-7196-4232
Andee KaplanDepartment of Statistics, Colorado State University, Fort Collins, Colorado, USA.
G Brooke AndersonDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado, USA.
Wen ZhouDepartment of Statistics, Colorado State University, Fort Collins, Colorado, USA.

Funding

Statistical methods for higher order dependences to understand protein functionsR01GM144961 · NIGMS · COLORADO STATE UNIVERSITY · PI ZHOU, WEN · 2021 to 2023
$600k
NIGMS NIH HHS R01 GM144961
6 · The paper itself

Abstract

The spread of COVID-19 has been greatly impacted by regulatory policies and behavior patterns that vary across counties, states, and countries. Population-level dynamics of COVID-19 can generally be described using a set of ordinary differential equations, but these deterministic equations are insufficient for modeling the observed case rates, which can vary due to local testing and case reporting policies and nonhomogeneous behavior among individuals. To assess the impact of population mobility on the spread of COVID-19, we have developed a novel Bayesian time-varying coefficient state-space model for infectious disease transmission. The foundation of this model is a time-varying coefficient compartment model to recapitulate the dynamics among susceptible, exposed, undetected infectious, detected infectious, undetected removed, hospitalized, detected recovered, and detected deceased individuals. The infectiousness and detection parameters are modeled to vary by time, and the infectiousness component in the model incorporates information on multiple sources of population mobility. Along with this compartment model, a multiplicative process model is introduced to allow for deviation from the deterministic dynamics. We apply this model to observed COVID-19 cases and deaths in several U.S. states and Colorado counties. We find that population mobility measures are highly correlated with transmission rates and can explain complicated temporal variation in infectiousness in these regions. Additionally, the inferred connections between mobility and epidemiological parameters, varying across locations, have revealed the heterogeneous effects of different policies on the dynamics of COVID-19.

Indexed as

COVID-19Epidemiological ModelsBayes TheoremHumansTime FactorsUnited StatesBayesian inferencecompartmental modelinfectious diseasemobilitymultiplicative process modeltime-varying coefficient

Identifiers

PMID35322455
PMCPMC9111166

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.