ReviewInternational endodontic journal2022
Present status and future directions of intracanal medicaments.
Review in International endodontic journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 114 citations in OpenAlex.
- Molecular analysis of intracanal microbial reduction to compare the effectiveness of glycyrrhizin and calcium hydroxide as intracanal medications: a randomised controlled trial.BMC oral health · 2026Trial
- Effect of simvastatin on expression of Interleukins 6 & 10 and Matrix Metalloproteinase: 9 when used as an intracanal medicament in teeth with symptomatic apical periodontitis-a triple blind randomized controlled trial.Journal of translational medicine · 2025Trial
- Trial
- Effect of Bio-C Temp calcium silicate-based intracanal medication on the chemical composition and fracture resistance of root dentin.Odontology · 2026Article
- Improbable healing in endodontics: a case series of favorable outcomes despite adverse prognostic conditions.BMC oral health · 2026Article
- Intracanal medicament removal revisited: A volumetric cone beam computed tomography analysis of four techniques.Journal of conservative dentistry and endodontics · 2026Article
- Comparative evaluation of irrigant activation devices for removal of calcium hydroxide from artificial isthmuses connecting curved canals in 3D-printed resin molar models.BMC oral health · 2026Article
- Efficacy of Calcium Silicate-Based, Simvastatin, Levofloxacin and Calcium Hydroxide Intracanal Medicaments Against Mature Enterococcus faecalis Biofilm. An In Vitro Study.Australian endodontic journal : the journal of the Australian Society of Endodontology Inc · 2026Article
- Article
- Targeted detection and antimicrobial susceptibility of common pathogens of failed root canal treatments: A cross-sectional study.Journal of conservative dentistry and endodontics · 2026Article
- Time-dependent effect of nanoparticle-based intracanal medicament on root dentin microhardness and their antibacterial efficacy againstJournal of conservative dentistry and endodontics · 2026Article
- Diabetes Mellitus and Endo-Periodontal Lesions: An HbA1c-Guided Framework for Clinical Decision-Making.Medicina (Kaunas, Lithuania) · 2026Review
- Comparative antibacterial efficacy of calcium hydroxide, diclofenac sodium, chitosan, and boric acid against Enterococcus faecalis: an in vitro study.Scientific reports · 2026Article
- A Comparative Study of Caerin 1.1/1.9 and Calcium Hydroxide in the Treatment of Apical Periodontitis in Rats.International dental journal · 2026Article
- Comparative antimicrobial efficacy of three intracanal medicaments in an in vitro Enterococcus faecalis root canal infection model.BMC oral health · 2026Article
- Cytocompatibility of calcium hydroxide medicament combined with cationic peptide - AnJournal of conservative dentistry and endodontics · 2026Article
- Cytocompatibility, osteogenic potential, antibacterial and antibiofilm efficacy of a calcium-silicate-based intracanal medication.Odontology · 2026Article
- The conundrum of current endodontic disinfection strategies in microbial load reduction: a scoping review.BMC oral health · 2026Article
- Bioactive peptides in Endodontic infections: The Good, The Bad, and The Ugly.Probiotics and antimicrobial proteins · 2026Review
- Zeolite-Y-Loaded Chitosan Nanoparticles as Endodontic Antimicrobial Agent: An In vitro Study.European journal of dentistry · 2026Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Two fundamental goals of endodontic treatment are to prevent or treat apical periodontitis. From a predictive perspective, several variables can affect the outcome of root canal treatment. Some of these variables depend on intraoperative factors, which include irrigation technique, size of the apical preparation, use of intracanal medicaments or the number of appointments necessary to complete the treatment. However, the outcome may also be affected by host and microbial factors. The intensity of periradicular bone loss or tissue damage, the presence of preoperative pain and associated conditions such as mechanical allodynia and central sensitization, the anatomical complexity of the apical portion of the canal, and the virulence and longevity of the bacterial infection can all have a profound influence on the outcome. Furthermore, numerous medical conditions have been reported to decrease the capability of the immune system to heal the periapical tissues. It is the clinician's responsibility to analyse these variables and incorporate them into the disinfection strategy to maximize the chances of healing. This narrative review will focus on the present status of intracanal medicaments, the clinical indications for their use and future directions for research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.