Evidence map›Paper›PMID 35322416›Full record

ArticleImmunology2022

1,25-Dihydroxyvitamin D3 suppresses CD4

Emma L Bishop, Nancy H Gudgeon, Gillian M Mackie, Daniel Chauss, Jennie Roberts, Daniel A Tennant, Kendle M Maslowski, Behdad Afzali, Martin Hewison, Sarah Dimeloe

Open access · hybridAbstract read
In one paragraph

Article in Immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Vitamin D supports activated CD4Frontiers in immunology · 2026
    Article
  5. Review
  6. Article
  7. 1,25-Dihydroxyvitamin DNutrients · 2023
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Emma L BishopInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Nancy H GudgeonInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Gillian M MackieInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Daniel ChaussImmunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, Maryland, USA.
Jennie RobertsInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.
Daniel A TennantInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.
Kendle M MaslowskiInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Behdad AfzaliImmunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, Maryland, USA.
Martin HewisonInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.
Sarah DimeloeInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.ORCID 0000-0002-4598-6518
University of Birmingham · GBNational Institutes of Health · US

Funding

Unravelling immunoregulatory circuits of tissue inflammationZIADK075149 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI AFZALI, BEHDAD · 2019 to 2025
$19.3M
A New Therapy for Bowel Ischemia-Reperfusion InjuryR44DK075149 · NIDDK · THERASOURCE, LLC · PI JACOB, ASHA · 2010 to 2012
$1.2M
New Therapy for Bowel Ischemia-Reperfusion InjuryR43DK075149 · NIDDK · THERASOURCE, LLC · PI WU, RONGQIAN · 2006 to 2007
$288k
Cancer Research UK 27112Intramural NIH HHS ZIA DK075149Medical Research Council MR/V011588/1NIDDK NIH HHS R43 DK075149NIDDK NIH HHS R44 DK075149Wellcome Trust
6 · The paper itself

Abstract

In CD4

Indexed as

CalcitriolInterferon-gammaGlycolysisT-Lymphocytes, Helper-InducerVitamin DCalcitriolInterferon-gammaVitamin DglycolysisimmunometabolismmetabolismT cellvitamin D

Identifiers

PMID35322416
PMCPMC9232967
OpenAlexW4220979967

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.