Evidence map›Paper›PMID 35322406›Full record

Observational studyDevelopmental medicine and child neurology2022

Modelling quality of life in children with intellectual disability using regression trees.

Peter Jacoby, Katrina Williams, Dinah Reddihough, Helen Leonard, Andrew Whitehouse, Jenny Downs

Open access · hybridAbstract readObservational Study
In one paragraph

Observational study in Developmental medicine and child neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Caregiver-reported quality of life in individuals with developmental and epileptic encephalopathy and other severe neurodevelopmental encephalopathies.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Observational
  10. Quality of life in people with intellectual and developmental disabilities.Developmental medicine and child neurology · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Peter JacobyTelethon Kids Institute, The University of Western Australia, Western Australia.ORCID 0000-0001-5092-7697
Katrina WilliamsPaediatric Education and Research, Monash University, Victoria.
Dinah ReddihoughDevelopmental Disability and Rehabilitation Research, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.ORCID 0000-0003-3634-7906
Helen LeonardTelethon Kids Institute, The University of Western Australia, Western Australia.ORCID 0000-0001-6405-5834
Andrew WhitehouseTelethon Kids Institute, The University of Western Australia, Western Australia.
Jenny DownsTelethon Kids Institute, The University of Western Australia, Western Australia.ORCID 0000-0001-7358-9037
The Kids Research Institute Australia · AUMonash University · AUMurdoch Children's Research Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo identify factors associated with quality of life (QoL) in children with intellectual disability. We aimed to identify patterns of association not observable in previous hypothesis-driven regression modelling using the same data set from a cross-sectional observational study.

methodA questionnaire was completed by 442 caregivers of children with confirmed intellectual disability and a diagnosis of autism spectrum disorder, cerebral palsy, Down syndrome, or Rett syndrome. The Quality of Life Inventory-Disability (QI-Disability) questionnaire was used to assess child QoL. Independent variables described the child's health, functional abilities, community participation, and sociodemographics. The R package rpart was used to build the regression trees.

resultsThe mean total QI-Disability score was 69.2 out of a maximum 100. The subgroup with the lowest QoL scores comprised children with a high degree of daytime sleepiness (n=74, mean 57.5) while the subgroup with the highest QoL scores (n=91, mean 80.3) comprised children with little daytime sleepiness who participated more frequently in community activities and displayed good eye contact while listening.

interpretationRegression tree analysis provides insights into the relative importance of associated factors. Sleep problems and community participation were more important than functional abilities in accounting for differences in QoL. WHAT THIS PAPER ADDS: A hypothesis-free regression tree analysis enables examination of multiple factors potentially influencing quality of life (QoL) in children with intellectual disability. Functional abilities were less strongly associated with QoL than sleep problems and community participation.

Indexed as

Autism Spectrum DisorderDisorders of Excessive SomnolenceIntellectual DisabilitySleep Wake DisordersChildCross-Sectional StudiesHumansQuality of LifeSurveys and Questionnaires

Identifiers

PMID35322406
PMCPMC9542381
OpenAlexW4220831210

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.