Evidence map›Paper›PMID 35322340›Full record

Trial reportNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2022

Does transcranial direct current stimulation enhance cognitive performance in Parkinson's disease mild cognitive impairment? An event-related potentials and neuropsychological assessment study.

Serkan Aksu, Atilla Uslu, Pınar İşçen, Emine Elif Tülay, Huzeyfe Barham, Ahmet Zihni Soyata, Asli Demirtas-Tatlidede, Gülsen Babacan Yıldız, Başar Bilgiç, Haşmet Hanağası and 3 more

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 5 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 5 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. TMS and tDCS as potential tools for the treatment of cognitive deficits in Parkinson's disease: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
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  6. Trial
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  8. Trial
  9. Review
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  11. Long-term use of tDCS-clinical and ethical considerations.Frontiers in human neuroscience · 2026
    Article
  12. Review
  13. Article
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  15. Clinical neurophysiology in the treatment of movement disorders: IFCN handbook chapter.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024
    Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 2 countries.

Serkan AksuDepartment of Physiology, Graduate School of Health Sciences, Istanbul University, Istanbul, Turkey. serkanaksu@mu.edu.tr.ORCID http://orcid.org/0000-0001-7715-0320
Atilla UsluDepartment of Physiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Pınar İşçenDepartment of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Emine Elif TülayDepartment of Software Engineering, Faculty of Engineering, Muğla Sıtkı Koçman University, Muğla, Turkey.
Huzeyfe BarhamDepartment of Psychiatry, Kırklareli Research and Training Hospital, Kırklareli, Turkey.
Ahmet Zihni SoyataDepartment of Psychiatry, Ergani State Hospital, Diyarbakır, Turkey.
Asli Demirtas-TatlidedeDepartment of Neurology, School of Medicine, Bahcesehir University, Istanbul, Turkey.
Gülsen Babacan YıldızPrivate Clinic, Istanbul, Turkey.
Başar BilgiçDepartment of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Haşmet HanağasıDepartment of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Adam J WoodsDepartment of Clinical and Health Psychology, Center for Cognitive Aging and Memory, McKnight Brain Institute, Cognitive Aging and Memory Clinical Translational Research Program, University of Florida, Gainesville, USA.
Sacit KaramürselDepartment of Physiology, School of Medicine, Koç University, Istanbul, Turkey.
Fatma Aytül UyarDepartment of Physiology, Graduate School of Health Sciences, Istanbul University, Istanbul, Turkey.
Istanbul University · TRBahçeşehir University · TRKırklareli University · TRKoç University · TRMuğla University · TRTurkish Society of Hematology · TRUniversity of Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundParkinson's disease-mild cognitive impairment (PD-MCI) is garnering attention as a key interventional period for cognitive impairment. Currently, there are no approved treatments for PD-MCI and encouraging results of transcranial direct current stimulation (tDCS) combined with other interventions have been proposed, though the efficacy and neural mechanisms of tDCS alone have not been studied in PD-MCI yet.

objectivesThe present double-blind, randomized, sham-controlled study assessed the effects of tDCS over the dorsolateral prefrontal cortex on cognitive functions via neuropsychological and electrophysiological evaluations in individuals with PD-MCI for the first time.

methodTwenty-six individuals with PD-MCI were administered 10 sessions of active (n = 13) or sham (n = 13) prefrontal tDCS twice a day, for 5 days. Changes were tested through a comprehensive neuropsychological battery and event-related potential recordings, which were performed before, immediately, and 1 month after the administrations.

resultsNeuropsychological assessment showed an improvement in delayed recall and executive functions in the active group. N1 amplitudes in response to targets in the oddball test-likely indexing attention and discriminability and NoGo N2 amplitudes in the continuous performance test-likely indexing cognitive control and conflict monitoring increased in the active group. Active stimulation elicited higher benefits 1 month after the administrations.

conclusionThe present findings substantiate the efficacy of tDCS on cognitive control and episodic memory, along with the neural underpinnings of cognitive control, highlighting its potential for therapeutic utility in PD-MCI.

trial registrationNCT 04,171,804. Date of registration: 21/11/2019.

Indexed as

Cognitive DysfunctionParkinson DiseaseTranscranial Direct Current StimulationCognitionDouble-Blind MethodEvoked PotentialsHumansNeuropsychological TestsPrefrontal CortexERPEvent-related potentialsMild cognitive impairmentNeuropsychological assessmentParkinson’s diseasetDCSTranscranial direct current stimulation

Identifiers

PMID35322340
OpenAlexW4221076735

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.