Evidence map›Paper›PMID 35322336›Full record

ReviewInfection2022

COVID-19-associated Cryptococcus infection (CACI): a review of literature and clinical pearls.

Dinesh Regalla, Mollie VanNatta, Mohammad Alam, Alexandre E Malek

Open access · bronzeAbstract readReview
In one paragraph

Review in Infection, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Global, Regional, and National Burden of Pulmonary Fungal Infections 1990-2021.American journal of respiratory and critical care medicine · 2025
    Article
  3. Article
  4. Article
  5. Developing Crowdsourced Clinical Registry Studies.The American journal of nursing · 2024
    Review
  6. Article
  7. Description of Cryptococcosis Following SARS-CoV-2 Infection: A Disease Survey Through the Mycosis Study Group Education and Research Consortium (MSG-19).Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
  8. Antifungal Resistance in Cryptococcal Infections.Pathogens (Basel, Switzerland) · 2024
    Review
  9. Pleiotropic roles of LAMMER kinase, Lkh1 in stress responses and virulence ofFrontiers in cellular and infection microbiology · 2024
    Article
  10. Article
  11. Meningeal cryptococcosis and SARS-CoV-2 infection in people living with HIV/AIDS.Biomedica : revista del Instituto Nacional de Salud · 2023
    Article
  12. Article
  13. Article
  14. Review
  15. Cerebrospinal fluid: a target of some fungi and an overview.Memorias do Instituto Oswaldo Cruz · 2023
    Article
  16. Article
  17. Review
  18. COVID-19 associated with cryptococcosis: a scoping review.Therapeutic advances in infectious disease
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Dinesh RegallaDivision of Infectious Diseases, Department of Medicine, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Mollie VanNattaDepartment of Pharmacy, Ochsner LSU Health Shreveport, Shreveport, LA, USA.
Mohammad AlamDivision of Infectious Diseases, Department of Medicine, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Alexandre E MalekDivision of Infectious Diseases, Department of Medicine, Louisiana State University Health Sciences Center, Shreveport, LA, USA. Alex.e.malek@gmail.com.
Louisiana State University Health Sciences Center Shreveport · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCryptococcal infection has been increasingly reported in patients with COVID-19 infection, but the epidemiological factors, presentation, diagnostic certainty, and outcome have not been well-described.

methodsWe reviewed the published cases of COVID-19-associated Cryptococcus infections (CACI) to shed the light on the burden of this infection.

resultsWe identified 13 patients with confirmed cryptococcal infection. Cryptococcus infection was primarily seen in patients with severe COVID-19 disease who received corticosteroids therapy and admitted to the intensive care unit. Pulmonary CACI was the most common reported infection followed by cryptococcal meningitis.

conclusionIn light of the high mortality rate, clinicians should maintain a high clinical suspicion of CACI in critically ill patients.

Indexed as

COVID-19CryptococcosisCryptococcusMeningitis, CryptococcalHumansCOVID-19CryptococcusFungusImmunosuppressiveOpportunistic infections

Identifiers

PMID35322336
PMCPMC8942802
OpenAlexW4220693550

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.