ArticleNature2022
AAV-delivered suppressor tRNA overcomes a nonsense mutation in mice.
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Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.
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99citing papers in PubMed
10.0field-weighted citation impact, top 1% of its field
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Who cites it
99 citing papers in PubMed, 124 citations in OpenAlex.
- Article
- White matter disorders at the intersection of transcription, RNA processing and translation.Nature reviews. Neurology · 2026Review
- Engineering suppressor tRNAs for effective treatment of Duchenne muscular dystrophy.Science advances · 2026Article
- Programmed repair of disease-causing UGA premature termination codons in mammalian brain.Nucleic acids research · 2026Article
- Intravenous administration of an engineered AAV9-gene-silencing vector suppresses human SOD1 and extends survival in an ALS mouse model.Nature communications · 2026Article
- Engineered tRNA reduces vision loss in a mouse model of Leber congenital amaurosis.Signal transduction and targeted therapy · 2026Article
- Engineered suppressor tRNAs enable precise translational control of genetic circuits in E. coli.Nucleic acids research · 2026Article
- Host mature tRNAome as a decoding switch regulates antiviral and proviral responses.Nature communications · 2026Article
- The regulation, function and disease relevance of cytoplasmic tRNAs.Nature reviews. Molecular cell biology · 2026Review
- Self-Assembling Short Peptide Carriers for Gene Delivery.International journal of molecular sciences · 2026Review
- Tetrahedral DNA nanostructure-delivered suppressor tRNA ameliorates nephropathy inNAR molecular medicine · 2026Article
- Mistranslation from an endogenous tRNA variant in human pan-genome cell lines.Nucleic acids research · 2026Article
- Anticodon-edited transfer RNAs (ACE-tRNAs) encoded as therapeutic nonviral minimal DNA vectors.Nucleic acids research · 2026Article
- Mistranslating tRNA variants impact the proteome and phosphoproteome of Saccharomyces cerevisiae.G3 (Bethesda, Md.) · 2026Article
- A Translational Roadmap for Neurological Nonsense Mutation Disorders.International journal of molecular sciences · 2026Review
- An engineered UGA suppressor tRNA gene for disease-agnostic AAV delivery.Nature biotechnology · 2026Article
- ENSURE: the encyclopedia of suppressor tRNA with an AI assistant.Nucleic acids research · 2026Article
- Single-strand deaminase-assisted editing for functional RNA manipulation.Nature biotechnology · 2026Article
- Programmable transcriptional condensates for enhanced CRISPR-based gene regulation.Theranostics · 2026Article
- AAV-delivered engineered suppressor tRNA rescues visual function in mice with an inherited retinal disease.Nature communications · 2025Article
39 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors at 1 institution in 1 country.
Jiaming Wang *Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0002-4834-967X
Yue Zhang *Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0003-1144-1445
Craig A Mendonca *Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0001-9938-6481
Onur YukselenProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Khaja MuneeruddinMass Spectrometry Facility, University of Massachusetts Chan Medical School, Shrewsbury, MA, USA.
Lingzhi RenHorae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Jialing LiangHorae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Chen ZhouHorae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Jun XieHorae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0001-9565-1567
Jia LiHorae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Zhong JiangDepartment of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Alper KucukuralProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0001-9983-394X
Scott A ShafferMass Spectrometry Facility, University of Massachusetts Chan Medical School, Shrewsbury, MA, USA.
Guangping GaoHorae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, MA, USA. Guangping.Gao@umassmed.edu.ORCID http://orcid.org/0000-0003-0097-9012
Dan WangHorae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, MA, USA. Dan.Wang@umassmed.edu.ORCID http://orcid.org/0000-0001-9079-2360
University of Massachusetts Chan Medical School · US
Funding
University of Massachusetts Center for Clinical Science and Translational SupplementUL1TR001453 · NCATS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LUZURIAGA, KATHERINE F · 2015 to 2024
$39.0MVector Immunology CoreP01HL158506 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Dan Wang · 2021 to 2026
$19.5MProject 4: A permanent off-switch for AAVU19AI149646 · NIAID · UNIVERSITY OF FLORIDA · PI FARZAN, MICHAEL R. · 2020 to 2024
$14.0MViral escape from AAV expressed transgenesP01AI100263 · NIAID · SCRIPPS FLORIDA · PI GAO, GUANGPING · 2012 to 2016
$11.9MViral Vector CoreP01HL131471 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI XUE, WEN · 2016 to 2020
$11.3MSustained antibody delivery for durable suppression of immunodeficiency virus replicationR01AI121135 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI David T Evans · 2015 to 2026
$6.9MOligodendrocyte-focused rAAV gene therapy strategies for Canavan disease and LeukodystrophiesR01NS076991 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Guangping Gao · 2012 to 2026
$5.7MNext Generation of Recombinant AAV Serotype Vectors for Gene TherapyR01HL097088 · NHLBI · UNIVERSITY OF FLORIDA · PI GAO, GUANGPING, HERZOG, ROLAND W. · 2010 to 2018
$5.4MDevelop combinatorial non-viral and viral CRISPR delivery for lung diseasesUH3HL147367 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ANDERSON, DANIEL G, GAO, GUANGPING · 2021 to 2022
$2.9MDevelop combinatorial non-viral and viral CRISPR delivery for lung diseasesUG3HL147367 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ANDERSON, DANIEL G, GAO, GUANGPING · 2018 to 2020
$2.7MFortilin, CTNNA3, and the HeartR01HL152723 · NHLBI · UNIVERSITY OF WASHINGTON · PI FUJISE, KEN · 2021 to 2024
$2.7MNCATS NIH HHS UL1 TR001453NHLBI NIH HHS P01 HL131471NHLBI NIH HHS P01 HL158506NHLBI NIH HHS R01 HL097088NHLBI NIH HHS R01 HL152723NHLBI NIH HHS UG3 HL147367NHLBI NIH HHS UH3 HL147367NIAID NIH HHS P01 AI100263NIAID NIH HHS R01 AI121135NIAID NIH HHS U19 AI149646NINDS NIH HHS R01 NS076991
Abstract
Gene therapy is a potentially curative medicine for many currently untreatable diseases, and recombinant adeno-associated virus (rAAV) is the most successful gene delivery vehicle for in vivo applications
Indexed as
Codon, NonsenseDependovirusGenetic TherapyAdenoviridaeAnimalsCodon, TerminatorGenetic Diseases, InbornGenetic VectorsHumansMiceNonsense Mediated mRNA DecayRNA, TransferCodon, NonsenseCodon, TerminatorRNA, Transfer
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.