ArticleCommunications biology2022
Megapixel camera arrays enable high-resolution animal tracking in multiwell plates.
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 57 citations in OpenAlex.
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- Natural variation suggests candidate genes underlying Caenorhabditis elegans susceptibility to diverse toxicants.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- High-throughput multi-camera array microscope platform for automated 3D behavioral analysis of swimming zebrafish larvae.Communications biology · 2026Article
- High-Throughput Toxicity Screening withEnvironmental science & technology · 2026Review
- Caenorhabditis elegans as an experimental model for resilience-boosting microbiota interventions in nonmodel ectotherms.FEMS microbiology reviews · 2026Review
- Natural variation suggests candidate genes underlyingbioRxiv : the preprint server for biology · 2025Article
- Quantitative ethology of schistosome miracidia characterizes a conserved snail peptide that inhibits host recognition.PLoS pathogens · 2025Article
- High-throughput multi-camera array microscope platform for automated 3D behavioral analysis of swimming zebrafish larvae.bioRxiv : the preprint server for biology · 2025Article
- High-throughput behavioural phenotyping of 25 C. elegans disease models including patient-specific mutations.BMC biology · 2025Article
- Article
- A neural network model enables worm tracking in challenging conditions and increases signal-to-noise ratio in phenotypic screens.PLoS computational biology · 2025Article
- High-throughput behavioral screening in Caenorhabditis elegans using machine learning for drug repurposing.Scientific reports · 2025Article
- Identification of a key peptide cyclase for novel cyclic peptide discovery in Pseudostellaria heterophylla.Plant communications · 2025Article
- A high precision method of segmenting complex postures in Caenorhabditis elegans and deep phenotyping to analyze lifespan.Scientific reports · 2025Article
- Recording dynamic facial micro-expressions with a multi-focus camera array.Biomedical optics express · 2025Article
- Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 4 countries.
Funding
Abstract
Tracking small laboratory animals such as flies, fish, and worms is used for phenotyping in neuroscience, genetics, disease modelling, and drug discovery. An imaging system with sufficient throughput and spatiotemporal resolution would be capable of imaging a large number of animals, estimating their pose, and quantifying detailed behavioural differences at a scale where hundreds of treatments could be tested simultaneously. Here we report an array of six 12-megapixel cameras that record all the wells of a 96-well plate with sufficient resolution to estimate the pose of C. elegans worms and to extract high-dimensional phenotypic fingerprints. We use the system to study behavioural variability across wild isolates, the sensitisation of worms to repeated blue light stimulation, the phenotypes of worm disease models, and worms' behavioural responses to drug treatment. Because the system is compatible with standard multiwell plates, it makes computational ethological approaches accessible in existing high-throughput pipelines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.