Evidence map›Paper›PMID 35322189›Full record

ArticleMucosal immunology2022

FoxO1 suppresses IL-10 producing B cell differentiation via negatively regulating Blimp-1 expression and contributes to allergic asthma progression.

Song-Rong Wang, Ren-Dong Hu, Min Ma, Xing You, Haiyan Cui, Yi He, Damo Xu, Zhi-Bin Zhao, Carlo Selmi, M Eric Gershwin and 2 more

Open access · bronzeAbstract read
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In one paragraph

Article in Mucosal immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Song-Rong Wang *Chronic Disease Laboratory, School of Medicine, South China University of Technology, Guangzhou, China.
Ren-Dong Hu *Chronic Disease Laboratory, School of Medicine, South China University of Technology, Guangzhou, China.
Min Ma *Chronic Disease Laboratory, School of Medicine, South China University of Technology, Guangzhou, China.
Xing YouSchool of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, 511442, P. R. China.
Haiyan CuiDepartment of Respiratory and Critical Care Medicine, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, 510630, China.
Yi HeDepartment of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong, 510630, China.
Damo XuState Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen Key Laboratory of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen, China.
Zhi-Bin ZhaoMedical Research Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Carlo SelmiRheumatology and Clinical Immunology, Humanitas Clinical and Research Center-IRCCS, Rozzano, Milan, Italy.
M Eric GershwinDivision of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA, USA.
Liang LiMedical Research Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China. lil2009@mail.ustc.edu.cn.
Zhe-Xiong LianChronic Disease Laboratory, School of Medicine, South China University of Technology, Guangzhou, China. zxlian1@ustc.edu.cn.
South China University of Technology · CNGuangdong Academy of Medical Sciences · CNThird Affiliated Hospital of Southern Medical University · CNHumanitas University · ITShenzhen University · CNUniversity of California, Davis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IL-10-producing B cells (B10) are involved in the prevention of autoimmune and allergic responses but its mechanisms remain poorly understood. We took advantage of the ovalbumin-induced asthma mouse model to demonstrate that the activity of FoxO1 is upregulated in lung B cells and correlates inversely with B10 cells, while showing decreased activity in ex vivo and in vitro induced B10 cells. We further observed that FoxO1 deficiency leads to increased frequency of B10 cells. These observations have in vivo clinical evidence, as B cell specific FoxO1 deficiency leads to reduced lung eosinophils and asthma remission in mice, and there are reduced regulatory B cells and increased FoxO1 activity in B cells of asthma patients. Single cell RNA-sequencing data demonstrated a negative correlation between the expression of Foxo1 and Il10 in B cells from the mouse spleen and lung and the human lung. For a biological mechanism, FoxO1 inhibits the expression of Prdm1, which encodes Blimp-1, a transcription factor of B10 cells. Our experimental evidence in both murine and human asthma demonstrates that FoxO1 is a negative regulator of B10 cell differentiation via negatively regulating Prdm1 and its expression in B cells contributes to allergic asthma disease.

Indexed as

AsthmaInterleukin-10AnimalsCell DifferentiationForkhead Box Protein O1HumansLymphocyte ActivationMicePositive Regulatory Domain I-Binding Factor 1Forkhead Box Protein O1FOXO1 protein, humanFoxo1 protein, mouseIL10 protein, humanIL10 protein, mouseInterleukin-10Positive Regulatory Domain I-Binding Factor 1PRDM1 protein, humanPrdm1 protein, mouse

Identifiers

PMID35322189
OpenAlexW4220658364

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.