Evidence map›Paper›PMID 35322175›Full record

ArticleCellular & molecular immunology2022

The RNA helicase DHX15 is a critical regulator of natural killer-cell homeostasis and functions.

Guangchuan Wang, Xiang Xiao, Yixuan Wang, Xiufeng Chu, Yaling Dou, Laurie J Minze, Rafik M Ghobrial, Zhiqiang Zhang, Xian C Li

Open access · greenAbstract read
In one paragraph

Article in Cellular & molecular immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Guangchuan WangImmunobiology and Transplant Science Center and Department of Surgery, Houston Methodist Hospital, Texas Medical Center, Houston, TX, USA.
Xiang XiaoImmunobiology and Transplant Science Center and Department of Surgery, Houston Methodist Hospital, Texas Medical Center, Houston, TX, USA.
Yixuan WangImmunobiology and Transplant Science Center and Department of Surgery, Houston Methodist Hospital, Texas Medical Center, Houston, TX, USA.
Xiufeng ChuImmunobiology and Transplant Science Center and Department of Surgery, Houston Methodist Hospital, Texas Medical Center, Houston, TX, USA.
Yaling DouImmunobiology and Transplant Science Center and Department of Surgery, Houston Methodist Hospital, Texas Medical Center, Houston, TX, USA.
Laurie J MinzeImmunobiology and Transplant Science Center and Department of Surgery, Houston Methodist Hospital, Texas Medical Center, Houston, TX, USA.
Rafik M GhobrialImmunobiology and Transplant Science Center and Department of Surgery, Houston Methodist Hospital, Texas Medical Center, Houston, TX, USA.
Zhiqiang ZhangImmunobiology and Transplant Science Center and Department of Surgery, Houston Methodist Hospital, Texas Medical Center, Houston, TX, USA.ORCID 0000-0003-1796-081X
Xian C LiImmunobiology and Transplant Science Center and Department of Surgery, Houston Methodist Hospital, Texas Medical Center, Houston, TX, USA. xcli@houstonmethodist.org.ORCID 0000-0002-5981-2762
Houston Methodist · US

Funding

Modulation of innate immune cells to create transplant toleranceR01AI080779 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI Xian Chang Li · 2011 to 2026
$5.2M
Studies of a new checkpoint regulator in the control of intestinal inflammationR01AI155488 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI ZHANG, ZHIQIANG · 2021 to 2025
$2.0M
NIAID NIH HHS R01 AI080779NIAID NIH HHS R01 AI155488
6 · The paper itself

Abstract

The RNA helicase DHX15 is widely expressed in immune cells and traditionally thought to be an RNA splicing factor or a viral RNA sensor. However, the role of DHX15 in NK-cell activities has not been studied thus far. Here, we generated Dhx15-floxed mice and found that conditional deletion of Dhx15 in NK cells (Ncr1

Indexed as

Interleukin-15RNA HelicasesAnimalsHomeostasisKiller Cells, NaturalMiceSignal TransductionDhx15 protein, mouseInterleukin-15RNA HelicasesDEAH-box helicase 15 (DHX15)HomeostasisIL-15 signaling pathwayInnate immunityNatural killer (NK) cells

Identifiers

PMID35322175
PMCPMC9151759
OpenAlexW4221001725

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.