Evidence map›Paper›PMID 35322078›Full record

ArticleScientific reports2022

Loss of KAP3 decreases intercellular adhesion and impairs intracellular transport of laminin in signet ring cell carcinoma of the stomach.

Tomohiro Soda, Yasuyuki Gen, Kei Terasaki, Naoto Iwai, Tomoko Kitaichi, Osamu Dohi, Hiroyoshi Taketani, Yuya Seko, Atsushi Umemura, Taichiro Nishikawa and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Tomohiro SodaDepartment of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kamigyo, Kyoto, 602-8566, Japan.
Yasuyuki GenDepartment of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kamigyo, Kyoto, 602-8566, Japan.
Kei TerasakiDepartment of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kamigyo, Kyoto, 602-8566, Japan.
Naoto IwaiDepartment of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kamigyo, Kyoto, 602-8566, Japan.
Tomoko KitaichiDepartment of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kamigyo, Kyoto, 602-8566, Japan.
Osamu DohiDepartment of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kamigyo, Kyoto, 602-8566, Japan.
Hiroyoshi TaketaniDepartment of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kamigyo, Kyoto, 602-8566, Japan.
Yuya SekoDepartment of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kamigyo, Kyoto, 602-8566, Japan.
Atsushi UmemuraDepartment of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kamigyo, Kyoto, 602-8566, Japan.
Taichiro NishikawaDepartment of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kamigyo, Kyoto, 602-8566, Japan.
Kanji YamaguchiDepartment of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kamigyo, Kyoto, 602-8566, Japan.
Michihisa MoriguchiDepartment of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kamigyo, Kyoto, 602-8566, Japan.
Hideyuki KonishiDepartment of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kamigyo, Kyoto, 602-8566, Japan.
Yuji NaitoDepartment of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kamigyo, Kyoto, 602-8566, Japan.
Yoshito ItohDepartment of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kamigyo, Kyoto, 602-8566, Japan.
Kohichiroh YasuiSchool of Health Sciences, Bukkyo University, Nakagyo, Kyoto, 604-8418, Japan. k-yasui@bukkyo-u.ac.jp.
Kyoto Prefectural University of Medicine · JPBukkyo University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Signet-ring cell carcinoma (SRCC) is a unique subtype of gastric cancer that is impaired for cell-cell adhesion. The pathogenesis of SRCC remains unclear. Here, we show that expression of kinesin-associated protein 3 (KAP3), a cargo adaptor subunit of the kinesin superfamily protein 3 (KIF3), a motor protein, is specifically decreased in SRCC of the stomach. CRISPR/Cas9-mediated gene knockout experiments indicated that loss of KAP3 impairs the formation of circumferential actomyosin cables by inactivating RhoA, leading to the weakening of cell-cell adhesion. Furthermore, in KAP3 knockout cells, post-Golgi transport of laminin, a key component of the basement membrane, was inhibited, resulting in impaired basement membrane formation. Together, these findings uncover a potential role for KAP3 in the pathogenesis of SRCC of the stomach.

Indexed as

Carcinoma, Signet Ring CellStomach NeoplasmsAdaptor Proteins, Signal TransducingCytoskeletal ProteinsHumansKinesinsLamininAdaptor Proteins, Signal TransducingCytoskeletal ProteinsKIFAP3 protein, humanKinesinsLaminin

Identifiers

PMID35322078
PMCPMC8943207
OpenAlexW4221080388

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.