Evidence map›Paper›PMID 35322058›Full record

ArticleScientific reports2022

Multicolor labeling of airway neurons and analysis of parasympathetic heterogeneity.

Alexandra B Pincus, Samuel J Huang, Katie M Lebold, Ubaldo De La Torre, Becky J Proskocil, Matthew G Drake, Hiroyuki Nakai, Allison D Fryer, David B Jacoby

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Alexandra B Pincus *Oregon Health & Science University, 3181 SW Sam Jackson Park Road, BRB 440, Portland, OR, 97239, USA. pincus@ohsu.edu.
Samuel J Huang *Oregon Health & Science University, 3181 SW Sam Jackson Park Road, BRB 440, Portland, OR, 97239, USA.
Katie M LeboldDepartment of Emergency Medicine, Stanford University School of Medicine, 900 Welch Rd, Palo Alto, CA, 94304, USA.
Ubaldo De La TorreOregon Health & Science University, 3181 SW Sam Jackson Park Road, BRB 440, Portland, OR, 97239, USA.
Becky J ProskocilOregon Health & Science University, 3181 SW Sam Jackson Park Road, BRB 440, Portland, OR, 97239, USA.
Matthew G DrakeOregon Health & Science University, 3181 SW Sam Jackson Park Road, BRB 440, Portland, OR, 97239, USA.
Hiroyuki NakaiOregon Health & Science University, 3181 SW Sam Jackson Park Road, BRB 440, Portland, OR, 97239, USA.
Allison D FryerOregon Health & Science University, 3181 SW Sam Jackson Park Road, BRB 440, Portland, OR, 97239, USA.
David B JacobyOregon Health & Science University, 3181 SW Sam Jackson Park Road, BRB 440, Portland, OR, 97239, USA.
Oregon Health & Science University · USStanford University · US

Funding

Identifying mechanisms and reversibility of eosinophil-induced airway hyperinnervation in asthmaR01HL155623 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI DRAKE, MATTHEW G. · 2021 to 2025
$3.3M
Program in Biomedical SciencesT32GM142619 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Jeffrey Wallace Tyner · 2021 to 2026
$3.2M
Prenatal control of offspring airway responsivenessR01HL144008 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI JACOBY, DAVID B · 2019 to 2022
$2.4M
Translational Vision Science Research at Oregon Health & Science UniversityT32EY023211 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Yali Jia, Kate E Keller · 2013 to 2026
$2.4M
Insulin Modulates Parasympathetic Nerve Control of LungsR01HL131525 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI FRYER, ALLISON DEBORAH · 2017 to 2020
$1.9M
An optogenetic approach to airway researchR21AI152498 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI JACOBY, DAVID B · 2020 to 2021
$424k
Airway sensory nerve changes in a mouse model of maternal allergen exposureF30HL145906 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI PINCUS, ALEXANDRA BOWMAN · 2019 to 2022
$200k
NEI NIH HHS T32 EY023211NHLBI NIH HHS F30 HL145906NHLBI NIH HHS HL131525NHLBI NIH HHS HL145906NHLBI NIH HHS R01 HL131525NHLBI NIH HHS R01 HL144008NHLBI NIH HHS R01 HL155623NIAID NIH HHS R21 AI152498NIGMS NIH HHS T32 GM142619
6 · The paper itself

Abstract

We report subpopulations of airway parasympathetic neurons expressing substance P, neuronal nitric oxide synthase, and tyrosine hydroxylase, highlighting unexplored heterogeneity in this population. These neurotransmitter-specific subpopulations did not form intraganglionic interneurons, but rather, extended outside the ganglia, into the airways, to distant innervation targets. Our experiments demonstrate the utility of multicolor labeling to characterize airway innervation, allowing us to confirm the extensive heterogeneity of postganglionic parasympathetic neurons. These methods will facilitate future investigations of neurophysiology and neural contributions to airway disease.

Indexed as

NeuronsNitric Oxide SynthaseGangliaRespiratory SystemTyrosine 3-MonooxygenaseNitric Oxide SynthaseTyrosine 3-Monooxygenase

Identifiers

PMID35322058
PMCPMC8943012
OpenAlexW4220934811

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.