Evidence map›Paper›PMID 35322021›Full record

ArticleNature communications2022

A distinct mechanism of C-type inactivation in the Kv-like KcsA mutant E71V.

Ahmed Rohaim, Bram J A Vermeulen, Jing Li, Felix Kümmerer, Federico Napoli, Lydia Blachowicz, João Medeiros-Silva, Benoît Roux, Markus Weingarth

Abstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Gating crosstalk in potassium channels.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. OPTO: Automated Optimization for Solid-State NMR Spectroscopy.Journal of the American Chemical Society · 2025
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ahmed Rohaim *Department of Biochemistry and Molecular Biology, The University of Chicago, 929 E 57th Street, Chicago, IL, 60637, USA.
Bram J A Vermeulen *NMR Spectroscopy, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands.ORCID 0000-0002-9798-6245
Jing LiDepartment of BioMolecular Sciences, School of Pharmacy, The University of Mississippi, University, MS, 38677, USA.ORCID 0000-0003-3277-6818
Felix KümmererNMR Spectroscopy, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands.
Federico NapoliNMR Spectroscopy, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands.ORCID 0000-0002-9043-136X
Lydia BlachowiczDepartment of Biochemistry and Molecular Biology, The University of Chicago, 929 E 57th Street, Chicago, IL, 60637, USA.ORCID 0000-0001-6407-0559
João Medeiros-SilvaNMR Spectroscopy, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands.ORCID 0000-0003-3532-4390
Benoît RouxDepartment of Biochemistry and Molecular Biology, The University of Chicago, 929 E 57th Street, Chicago, IL, 60637, USA. roux@uchicago.edu.ORCID 0000-0002-5254-2712
Markus WeingarthNMR Spectroscopy, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands. m.h.weingarth@uu.nl.ORCID 0000-0003-0831-8673

Funding

Synthetic Antigen Binder CoreU54GM087519 · NIGMS · UNIVERSITY OF CHICAGO · PI PEROZO, EDUARDO A · 2010 to 2017
$31.9M
Computational Studies of Ion Channels - Resubmission 01R01GM062342 · NIGMS · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI ROUX, BENOIT · 2001 to 2022
$8.7M
NIGMS NIH HHS R01 GM062342NIGMS NIH HHS U54 GM087519
6 · The paper itself

Abstract

C-type inactivation is of great physiological importance in voltage-activated K

Indexed as

Bacterial ProteinsPotassium ChannelsCrystallography, X-RayProtein ConformationBacterial ProteinsPotassium Channels

Identifiers

PMID35322021
PMCPMC8943062

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.