ArticleNature communications2022
Design of stable and self-regulated microbial consortia for chemical synthesis.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
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- ROS/pH-Responsive Phenylboronic Acid-Chitosan Nanoparticles Improve Silymarin-Mediated Hepatoprotection After Hepatectomy With Gut-Liver Axis-Associated Responses.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Intelligent Plasmonic Bio-Holoelectrochemical Systems: A Testable Architecture for Light-Programmed Microbial Electrochemistry.Global challenges (Hoboken, NJ) · 2026Review
- Niche Construction: A Rational Engineering Strategy for Regulating Microbial Assembly to Enhance Flavor and Bioactivity of Fermented Foods.Comprehensive reviews in food science and food safety · 2026Review
- Different co-culture approaches to increase metabolites in foods.Food science and biotechnology · 2026Review
- Programmable cell-cell adhesion in synthetic yeast communities for improved bioproduction.Nature chemical biology · 2026Article
- Burden-aware feedback control of microbial consortia.Nature communications · 2026Article
- The mechanism and application of the selenium hyperaccumulator Cardamine hupingshanensis: status and challenges.Annals of botany · 2026Review
- Microbial stewardship for sustainable dye remediation with a special emphasis on consortia engineering, computational techniques, and microbial bioprospecting.Archives of microbiology · 2026Review
- Metabolic and plasmid engineering to produce D-phenyllactic acid from glucose-xylose co-substrates inApplied and environmental microbiology · 2025Article
- Intracellularly coupled oscillators for synthetic biology.Nature communications · 2025Review
- Engineering a Robust Escherichia coli W Platform for Scalable Production of Flavonoid-O-Glucosides.Microbial biotechnology · 2025Article
- Ty retrotransposon element based multiple integration toolkit forSynthetic and systems biotechnology · 2025Article
- Microbial consortia for the conversion of biomass into fuels and chemicals.Nature communications · 2025Review
- Biosynthesis and yield improvement strategies of fengycin.Archives of microbiology · 2025Review
- Insights from metagenomics on microbial biosynthesis of vitamins B and KFrontiers in veterinary science · 2025Article
- Editorial: Microbial co-cultures: a new era of synthetic biology and metabolic engineering, volume II.Frontiers in microbiology · 2025Article
- Assembly of functional microbial ecosystems: from molecular circuits to communities.FEMS microbiology reviews · 2024Review
- Spectral Algal Fingerprinting and Long Sequencing in Synthetic Algal-Microbial Communities.Cells · 2024Article
- Programming Dynamic Division of Labor Using Horizontal Gene Transfer.ACS synthetic biology · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microbial coculture engineering has emerged as a promising strategy for biomanufacturing. Stability and self-regulation pose a significant challenge for the generation of intrinsically robust cocultures for large-scale applications. Here, we introduce the use of multi-metabolite cross-feeding (MMCF) to establish a close correlation between the strains and the design rules for selecting the appropriate metabolic branches. This leads to an intrinicially stable two-strain coculture where the population composition and the product titer are insensitive to the initial inoculation ratios. With an intermediate-responsive biosensor, the population of the microbial coculture is autonomously balanced to minimize intermediate accumulation. This static-dynamic strategy is extendable to three-strain cocultures, as demonstrated with de novo biosynthesis of silybin/isosilybin. This strategy is generally applicable, paving the way to the industrial application of microbial cocultures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.