Evidence map›Paper›PMID 35321880›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2022

Influence of Self-MHC Class I Recognition on the Dynamics of NK Cell Responses to Cytomegalovirus Infection.

Marc Potempa, Oscar A Aguilar, Maria D R Gonzalez-Hinojosa, Iliana Tenvooren, Diana M Marquez, Matthew H Spitzer, Lewis L Lanier

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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  3. Review
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Marc PotempaDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA.ORCID 0000-0003-3853-3948
Oscar A AguilarDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA.ORCID 0000-0002-7990-8745
Maria D R Gonzalez-HinojosaDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA.
Iliana TenvoorenDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA.ORCID 0000-0002-9833-7669
Diana M MarquezDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA.ORCID 0000-0001-5343-8696
Matthew H SpitzerDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA.ORCID 0000-0002-5291-3819
Lewis L LanierDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA; lewis.lanier@ucsf.edu.ORCID 0000-0003-1308-3952
University of California, San Francisco · US

Funding

Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VAISSE, CHRISTIAN · 2003 to 2019
$21.8M
Microbial Pathogenesis and Host DefenseT32AI060537 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joanne N. Engel · 2004 to 2026
$6.5M
NK MemoryR01AI068129 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LANIER, LEWIS LEE · 2006 to 2020
$6.0M
Modeling Antibody-induced Immune Responses by NK cells in Mice and Humans (Resubmission 1)R01AI146581 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI DAS, JAYAJIT · 2020 to 2025
$2.3M
UCSF DVS CyTOF Mass CytometerS10OD018040 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LANIER, LEWIS LEE · 2014 to 2014
$600k
Modeling Antibody-induced Immune Responses by NK cells in Mice and HumansR56AI146581 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI DAS, JAYAJIT · 2019 to 2019
$512k
NIAID NIH HHS R01 AI068129NIAID NIH HHS R01 AI146581NIAID NIH HHS R56 AI146581NIAID NIH HHS T32 AI060537NIDDK NIH HHS P30 DK063720NIH HHS S10 OD018040
6 · The paper itself

Abstract

Although interactions between inhibitory Ly49 receptors and their self-MHC class I ligands in C57BL/6 mice are known to limit NK cell proliferation during mouse CMV (MCMV) infection, we created a 36-marker mass cytometry (CyTOF) panel to investigate how these inhibitory receptors impact the NK cell response to MCMV in other phenotypically measurable ways. More than two thirds of licensed NK cells (i.e., those expressing Ly49C, Ly49I, or both) in uninfected mice had already differentiated into NK cells with phenotypes indicative of Ag encounter (KLRG1

Indexed as

Cytomegalovirus InfectionsMuromegalovirusAnimalsKiller Cells, NaturalMiceMice, Inbred C57BLNK Cell Lectin-Like Receptor Subfamily ANK Cell Lectin-Like Receptor Subfamily A

Identifiers

PMID35321880
PMCPMC8976824
OpenAlexW4220752688

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.