ArticleBMC medicine2022
The relationships between women's reproductive factors: a Mendelian randomisation analysis.
Article in BMC medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- Women's reproductive life patterns, intrinsic capacity, and the risk of all-cause and cause-specific dementia: a prospective cohort study.Alzheimer's research & therapy · 2026Article
- IL3RA identified as novel biomarker and therapeutic target for ERClinical proteomics · 2026Article
- Reproductive history and later-life health: examining the link between birth intervals and CKD in postmenopausal women.BMC nephrology · 2026Article
- Adiposity and reproductive characteristics across the lifespan: a multi-ethnic population-based study in Northwest China.Reproductive health · 2026Article
- Assessing the causal and independent impact of parity-related reproductive factors on risk of breast cancer subtypes.BMC medicine · 2025Article
- Age at First Childbirth and Dementia Risk: A Cross-Sectional Ecological Analysis of Female Prevalence, Sex Disparities, and Public Health Implications.Health science reports · 2025Article
- Association of dietary flavonoid intake with reproductive lifespan: a cross-sectional study.European journal of nutrition · 2025Article
- Article
- Variables associated with cognitive function: an exposome-wide and mendelian randomization analysis.Alzheimer's research & therapy · 2025Article
- Article
- The causal effect of reproductive factors on pelvic floor dysfunction: a Mendelian randomization study.BMC women's health · 2024Article
- Causal associations between female reproductive behaviors and psychiatric disorders: a lifecourse Mendelian randomization study.BMC psychiatry · 2023Article
- Effect of women's fertility and sexual development on epigenetic clock: Mendelian randomization study.Clinical epigenetics · 2023Article
- Establishing the relationships between adiposity and reproductive factors: a multivariable Mendelian randomization analysis.BMC medicine · 2023Article
- Genetic causal relationship between age at menarche and benign oesophageal neoplasia identified by a Mendelian randomization study.Frontiers in endocrinology · 2023Article
- Women's reproductive traits and ischemic stroke: a two-sample Mendelian randomization study.Annals of clinical and translational neurology · 2023Article
- Review of mendelian randomization studies on age at natural menopause.Frontiers in endocrinology · 2023Review
- Impact of modifiable reproductive factors on cancer incidence and mortality in Korea: a systematic review protocol.BMJ open · 2022Article
- Associations between abdominal adipose tissue, reproductive span, and brain characteristics in post-menopausal women.NeuroImage. Clinical · 2022Article
- Mendelian randomization analysis of the causal association of bone mineral density and fracture with multiple sclerosis.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundWomen's reproductive factors include their age at menarche and menopause, the age at which they start and stop having children and the number of children they have. Studies that have linked these factors with disease risk have largely investigated individual reproductive factors and have not considered the genetic correlation and total interplay that may occur between them. This study aimed to investigate the nature of the relationships between eight female reproductive factors.
methodsWe used data from the UK Biobank and genetic consortia with data available for the following reproductive factors: age at menarche, age at menopause, age at first birth, age at last birth, number of births, being parous, age first had sexual intercourse and lifetime number of sexual partners. Linkage disequilibrium score regression (LDSC) was performed to investigate the genetic correlation between reproductive factors. We then applied Mendelian randomisation (MR) methods to estimate the causal relationships between these factors. Sensitivity analyses were used to investigate directionality of the effects, test for evidence of pleiotropy and account for sample overlap.
resultsLDSC indicated that most reproductive factors are genetically correlated (r
conclusionThis study presents evidence that women's reproductive factors are genetically correlated and causally related. Future studies examining the health sequelae of reproductive factors should consider a woman's entire reproductive history, including the causal interplay between reproductive factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.