ArticleSports health
Neural Correlates of Self-Reported Knee Function in Individuals After Anterior Cruciate Ligament Reconstruction.
Article in Sports health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Neural activity differences and their functional and clinical correlates after anterior cruciate ligament reconstruction: A systematic review of task-based fMRI studies.Experimental brain research · 2026Pooled it
- Cerebellar and Subcortical Connectivity Associated with Arthrogenic Muscle Inhibition After Acute ACL Rupture in Males: A Clinical and fMRI Study.Sports medicine - open · 2026Article
- The effect of MI-BCI combined with tDCS in early rehabilitation after anterior cruciate ligament reconstruction monitored by resting-state fMRI: the first case report.BMC neurology · 2026Article
- Exploratory EEG-TMS Study Reveals Altered Behavioral Function in Individuals Following Anterior Cruciate Ligament Reconstruction.Brain sciences · 2026Article
- The Presence of Mechanoreceptors and Cortical Connections Support a Proprioceptive Role for Knee Plicae.Arthroscopy, sports medicine, and rehabilitation · 2025Article
- Advances in Research on Brain Structure and Activation Characteristics in Patients with Anterior Cruciate Ligament Reconstruction: A Systematic Review.Brain sciences · 2025Review
- Functional Asymmetries After 6 Months of ACL Reconstruction: A Cross-Sectional Study.International wound journal · 2025Article
- Neurosciences and Sports Rehabilitation in ACLR: A Narrative Review on Winning Alliance Strategies and Connecting the Dots.Journal of functional morphology and kinesiology · 2025Review
- fMRI Activation in Sensorimotor Regions at 6 Weeks After Anterior Cruciate Ligament Reconstruction.The American journal of sports medicine · 2025Article
- Neurophysiology of ACL Injury.Orthopedic reviews · 2025Article
- Requirement of a complex motor task to identify neuroplastic changes in motor control of the lower extremity in patients with anterior cruciate ligament reconstruction: a fNIRS study.Frontiers in human neuroscience · 2025Article
- High magnitude exposure to repetitive head impacts alters female adolescent brain activity for lower extremity motor control.Brain research · 2024Article
- Neural functions vary by return-to-sport status in participants with anterior cruciate ligament reconstruction: a retrospective cohort study using sub-bands of resting-state functional magnetic resonance.Frontiers in human neuroscience · 2024Article
- Brain activity associated with quadriceps strength deficits after anterior cruciate ligament reconstruction.Scientific reports · 2023Article
- Organization of sensorimotor activity in anterior cruciate ligament reconstructed individuals: an fMRI conjunction analysis.Frontiers in human neuroscience · 2023Article
- The Missing Link.Sports healthArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnterior cruciate ligament (ACL) rupture is a common knee injury among athletes and physically active adults. Despite surgical reconstruction and extensive rehabilitation, reinjuries are common and disability levels are high, even years after therapy and return to activity. Prolonged knee dysfunction may result in part from unresolved neuromuscular deficits of the surrounding joint musculature in response to injury. Indeed, "upstream" neurological adaptations occurring after injury may explain these persistent functional deficits. Despite evidence for injury consequences extending beyond the joint to the nervous system, the link between neurophysiological impairments and patient-reported measures of knee function remains unclear. HYPOTHESIS: Patterns of brain activation for knee control are related to measures of patient-reported knee function in individuals after ACL reconstruction (ACL-R). STUDY
designCross-sectional study. LEVEL OF EVIDENCE: Level 3.
methodsIn this multicenter, cross-sectional study, participants with unilateral ACL-R (n = 25; 10 men, 15 women) underwent task-based functional magnetic resonance imaging testing. Participants performed repeated cycles of open-chain knee flexion/extension. Neural activation patterns during the movement task were quantified using blood oxygen level-dependent (BOLD) signals. Regions of interest were generated using the Juelich Histological Brain Atlas. Pearson product-moment correlations were used to determine the relationship between mean BOLD signal within each brain region and self-reported knee function level, as measured by the International Knee Documentation Committee index. Partial correlations were also calculated after controlling for time from surgery and sex.
resultsPatient-reported knee function was positively and moderately correlated with the ipsilateral secondary somatosensory cortex (
conclusionIncreased ipsilateral secondary sensorimotor cortical activity is related to higher perceived knee function. CLINICAL RELEVANCE: Central nervous system mechanisms for knee control are related to subjective levels of knee function after ACL-R. Increased neural activity may reflect central neuroplastic strategies to preserve knee functionality after traumatic injury.
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