ReviewFrontiers in neurology2022
Pain and the Triple Network Model.
Review in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
82 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Brain modulatory effects of rehabilitation interventions in fibromyalgia: a systematic review of magnetic resonance imaging studies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Pooled it
- Multimodal abnormalities of brain function in chronic low back pain: a systematic review and meta-analysis of neuroimaging studies.Frontiers in neuroscience · 2025Pooled it
- Brain functional changes following spinal manipulation therapy in patients with lumbar disc herniation and chronic low back pain: a scoping review.Frontiers in neurology · 2025Pooled it
- The Effects of Digital Cognitive Behavioral Therapy for Insomnia in Chronic Pain: A Randomized Controlled Trial.Psychotherapy and psychosomatics · 2026Trial
- Can EEG-Neurofeedback Training Enhance Effective Connectivity in People With Chronic Secondary Musculoskeletal Pain? A Secondary Analysis of a Feasibility Randomized Controlled Clinical Trial.Brain and behavior · 2025Trial
- Closed-Loop Infraslow Brain-Computer Interface can Modulate Cortical Activity and Connectivity in Individuals With Chronic Painful Knee Osteoarthritis: A Secondary Analysis of a Randomized Placebo-Controlled Clinical Trial.Clinical EEG and neuroscience · 2025Trial
- A safety and feasibility randomized placebo controlled trial exploring electroencephalographic effective connectivity neurofeedback treatment for fibromyalgia.Scientific reports · 2025Trial
- Telehealth-delivered cognitive behavioral therapy - a potential solution to improve sleep quality and normalize the salience network in fibromyalgia: a pilot randomized trial.Brain imaging and behavior · 2024Trial
- A Randomized Controlled Neuroimaging Trial of Cognitive Behavioral Therapy for Fibromyalgia Pain.Arthritis & rheumatology (Hoboken, N.J.) · 2024Trial
- Chiropractic Care Is Associated with Frequency-Specific Reorganisation of Triple-Network Brain Dynamics: A Source-Localised EEG Study.Brain sciences · 2026Article
- Brain imaging-wide exploration of site-specific pain: genetic correlation and Mendelian randomization study.Psychological medicine · 2026Article
- Non-Invasive Brain Stimulation for Core Symptoms of Chronic Primary Pain: A Meta-Analysis of RCTs.Brain sciences · 2026Review
- Sensory Blurring in Nociplastic Pain: The Role of Descending Inhibitory Dysfunction and Gut-Brain Axis Alterations in Older Adults.Geriatrics (Basel, Switzerland) · 2026Review
- From the Pain Matrix to Functional Networks: A Narrative Review of Chronic Pain Mechanisms Across Adult and Pediatric Populations with Emerging AI Perspectives.Brain sciences · 2026Review
- Oscillatory edge connectivity in pain-related regions supports machine learning identification of migraine.The journal of headache and pain · 2026Article
- From Prediction to Monitoring: Toward a Translational Framework of Biomarkers in Spinal Cord Stimulation.Biomedicines · 2026Review
- The importance of enworlded selfhood for understanding chronic pain-related suffering.Theoretical medicine and bioethics · 2026Article
- Early Changes in Resting-State Connectivity of the Anterior Insular Cortex Are Associated with Reductions in Pain and Catastrophizing After Total Hip Arthroplasty in Female Patients: A Preliminary Study.Journal of clinical medicine · 2026Article
- Multidimensional Analysis of Physical, Psychosocial, and Cognitive Impairment in People with Chronic Neck Pain.Medicina (Kaunas, Lithuania) · 2026Article
- Physiological Measures of Reduced Listening Effort in Active Noise Canceling: Evidence From a Low-β Functional Network in an Event-Related Potential Study.Clinical and experimental otorhinolaryngology · 2026Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute pain is a physiological response that causes an unpleasant sensory and emotional experience in the presence of actual or potential tissue injury. Anatomically and symptomatically, chronic pathological pain can be divided into three distinct but interconnected pathways, a lateral "painfulness" pathway, a medial "suffering" pathway and a descending pain inhibitory circuit. Pain (fullness) can exist without suffering and suffering can exist without pain (fullness). The triple network model is offering a generic unifying framework that may be used to understand a variety of neuropsychiatric illnesses. It claims that brain disorders are caused by aberrant interactions within and between three cardinal brain networks: the self-representational default mode network, the behavioral relevance encoding salience network and the goal oriented central executive network. A painful stimulus usually leads to a negative cognitive, emotional, and autonomic response, phenomenologically expressed as pain related suffering, processed by the medial pathway. This anatomically overlaps with the salience network, which encodes behavioral relevance of the painful stimuli and the central sympathetic control network. When pain lasts longer than the healing time and becomes chronic, the pain- associated somatosensory cortex activity may become functionally connected to the self-representational default mode network, i.e., it becomes an intrinsic part of the self-percept. This is most likely an evolutionary adaptation to save energy, by separating pain from sympathetic energy-consuming action. By interacting with the frontoparietal central executive network, this can eventually lead to functional impairment. In conclusion, the three well-known pain pathways can be combined into the triple network model explaining the whole range of pain related co-morbidities. This paves the path for the creation of new customized and personalized treatment methods.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.