ArticleNature and science of sleep2022
Effects of Caffeine Intake on Cognitive Performance Related to Total Sleep Deprivation and Time on Task: A Randomized Cross-Over Double-Blind Study.
Article in Nature and science of sleep, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Caffeinated Brain Part 2: The Effect of Caffeine on Sleep-Related Electroencephalography (EEG)-A Systematic and Mechanistic Review.Nutrients · 2026Pooled it
- Caffeine Intake Alters Recovery Sleep after Sleep Deprivation.Nutrients · 2024Trial
- Relationship between Habitual Caffeine Consumption, Attentional Performance, and Individual Alpha Frequency during Total Sleep Deprivation.International journal of environmental research and public health · 2023Trial
- Application of Filter Bank to Improve Fatigue Monitoring in Wearable EEG-Based Brain-Computer Interface.NeuroSci · 2026Article
- Characterizing alterations in attention networks under high mental workload.Scientific reports · 2026Article
- The intervention effect of caffeine oral tablets on mental fatigue induced by nap deprivation: based on assessments of heart rate variability, cognitive performance and subjective fatigue-a pilot study.Frontiers in public health · 2026Article
- Exploring the differences in neural oscillation mechanisms before and after sleep deprivation.Frontiers in neuroscience · 2026Article
- Combined effects of moderate normobaric hypoxia and sleep restriction on visual and auditory integration.Scientific reports · 2025Article
- A New Method for Inducing Mental Fatigue: A High Mental Workload Task Paradigm Based on Complex Cognitive Abilities and Time Pressure.Brain sciences · 2025Article
- A continuous approach to explain insomnia and subjective-objective sleep discrepancy.Communications biology · 2025Article
- Metabolic Characteristics of Gut Microbiota and Insomnia: Evidence from a Mendelian Randomization Analysis.Nutrients · 2024Article
- The evaluation of cEEGrids for fatigue detection in aviation.Sleep advances : a journal of the Sleep Research Society · 2024Article
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Corrections and comments
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Authors and funding
12 authors.
Funding
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Abstract
Introduction: It is widely admitted that both total sleep deprivation (TSD) and extended task engagement (Time-On-Task, TOT) induce a cognitive fatigue state in healthy subjects. Even if EEG theta activity and adenosine both increase with cognitive fatigue, it remains unclear if these modifications are common mechanisms for both sustained attention and executive processes. Methods: We performed a double-blind counter-balanced (placebo (PCBO) and caffeine (CAF) - 2×2.5 mg/kg/24 h)) study on 24 healthy subjects (33.7 ± 5.9 y). Subjects participated in an experimental protocol including an habituation/training day followed by a baseline day (D0 and D1) and a total sleep deprivation (TSD) day beginning on D1 at 23:00 until D2 at 21:00. Subjects performed the psychomotor vigilance test (PVT) assessing sustained attention, followed by the executive Go-NoGo inhibition task and the 2-NBack working memory task at 09:15 on D1 and D2. Results: We showed differential contributions of TSD and TOT on deficits in sustained attention and both executive processes. An alleviating effect of caffeine intake is only observed on sustained attention deficits related to TSD and not at all on TOT effect. The caffeine dose slows down the triggering of sustained attention deficits related to TOT effect. Discussion: These results suggest that sustained attention deficits induced by TSD rely on the adenosinergic mechanism whereas TOT effect observed for both sustained attention and executive would not.
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