Evidence map›Paper›PMID 35321271›Full record

ReviewWorld journal of gastrointestinal oncology2022

Clinical significance of molecular subtypes of gastrointestinal tract adenocarcinoma.

Ekaterina Olegovna Ignatova, Evgenii Kozlov, Maxim Ivanov, Vladislav Mileyko, Sofia Menshikova, Henian Sun, Mikhail Fedyanin, Alexey Tryakin, Ivan Stilidi

Abstract readReview
In one paragraph

Review in World journal of gastrointestinal oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Research advances in the molecular classification of gastric cancer.Cellular oncology (Dordrecht, Netherlands) · 2024
    Review
  5. Article
  6. Article
  7. OLIGOMETASTASIS IN GASTRIC CANCER TREATMENT: IS THERE A PLACE FOR THE SURGEON?Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2023
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ekaterina Olegovna IgnatovaDepartment of Second Chemotherapy, Federal State Budgetary Institution "N.N. Blokhin National Medical Research Center of Oncology" of the Ministry of Health of the Russian Federation, Moscow 115478, Moscow, Russia.
Evgenii KozlovOncoAtlas LLC, Moscow 121069, Moscow, Russia.
Maxim IvanovDepartment of Biological and Medical Physics, Moscow Institute of Physics and Technology, Moscow 141700, Moscow, Russia.
Vladislav MileykoOncoAtlas LLC, Moscow 121069, Moscow, Russia.
Sofia MenshikovaDepartment of Anticancer Drug Treatment, AO K31 City, Moscow 121552, Moscow, Russia.
Henian SunPirogov Russian National Research Medical University (Pirogov Medical University), Moscow 117997, Moscow, Russia.
Mikhail FedyaninDepartment of Second Chemotherapy, Federal State Budgetary Institution "N.N. Blokhin National Medical Research Center of Oncology" of the Ministry of Health of the Russian Federation, Moscow 115478, Moscow, Russia.
Alexey TryakinDepartment of Second Chemotherapy, Federal State Budgetary Institution "N.N. Blokhin National Medical Research Center of Oncology" of the Ministry of Health of the Russian Federation, Moscow 115478, Moscow, Russia.
Ivan StilidiDepartment of Second Chemotherapy, Federal State Budgetary Institution "N.N. Blokhin National Medical Research Center of Oncology" of the Ministry of Health of the Russian Federation, Moscow 115478, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adenocarcinomas of the gastrointestinal tract (esophagus, stomach, and colon) represent a heterogeneous group of diseases with distinct etiology, clinical features, treatment approaches, and prognosis. Studies are ongoing to isolate molecular genetic subtypes, perform complete biological characterization of the tumor, determine prognostic groups, and find predictive markers to the effectiveness of therapy. Separate molecular genetic classifications were created for esophageal adenocarcinoma [The Cancer Genome Atlas (TCGA)], stomach cancer (TCGA, Asian Cancer Research Group), and colon cancer (Colorectal Cancer Subtyping Consortium). In 2018, isolation of TCGA molecular genetic subtypes for adenocarcinomas of the gastrointestinal tract (esophagus, stomach, and colon) highlighted the need for further studies and clinical validation of subtyping of gastrointestinal adenocarcinomas. However, this approach has limitations. The aim of our work was to critically analyze integration of molecular genetic subtyping of gastrointestinal adenocarcinomas in clinical practice.

Indexed as

Colon cancerEsophageal adenocarcinomaGastric cancerGene sequencing, Gene expression profilingMolecular subtypes

Identifiers

PMID35321271
PMCPMC8919013

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.