Evidence map›Paper›PMID 35321256›Full record

ArticleMacromolecular research2021

Modifying Polydiacetylene Vesicle Compositions to Reduce Non-Specific Interactions.

Gumaro Rojas, Priyanka Shiveshwarkar, Butaek Lim, Anura Shrestha, Izele Abure, Anthony Nelson, Justyn Jaworski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Macromolecular research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gumaro RojasDepartment of Bioengineering, University of Texas at Arlington, Arlington, Texas, 76010, U.S.A.
Priyanka ShiveshwarkarDepartment of Bioengineering, University of Texas at Arlington, Arlington, Texas, 76010, U.S.A.
Butaek LimDepartment of Bioengineering, University of Texas at Arlington, Arlington, Texas, 76010, U.S.A.
Anura ShresthaDepartment of Bioengineering, University of Texas at Arlington, Arlington, Texas, 76010, U.S.A.
Izele AbureDepartment of Bioengineering, University of Texas at Arlington, Arlington, Texas, 76010, U.S.A.
Anthony NelsonDepartment of Bioengineering, University of Texas at Arlington, Arlington, Texas, 76010, U.S.A.
Justyn JaworskiDepartment of Bioengineering, University of Texas at Arlington, Arlington, Texas, 76010, U.S.A.

Funding

Development of novel liposome-based assays for quantifying anti-glycan antibody levels in serumR15GM135892 · NIGMS · UNIVERSITY OF TEXAS ARLINGTON · PI JAWORSKI, JUSTYN · 2019 to 2019
$373k
NIGMS NIH HHS R15 GM135892
6 · The paper itself

Abstract

Polydiacetylene (PDA) vesicles provide useful stimuli-responsive behavior as well as by the modular structure afford a means for the design of sensing and delivery systems with tunable target specificity. To reduce inherent non-specific interaction with either anionic or cationic formulations of polydiacetylene vesicles, we explored the use of various lengths of poly(ethylene glycol) (PEG) amphiphiles for integration and polymerization within PDA vesicles. Our results established that as little as 1% of polyethylene glycol amphiphile integration into anionic vesicles was sufficient to significantly reduce non-specific association with mammalian cells. Similarly integrating a low percent of PEG amphiphile content within cationic vesicles could also significantly reduce non-specific cell association, and moreover reduced cytotoxicity. These results may be prove useful in augmenting PDA vesicles formulations for reduced non-specific interaction which is of particularly interest to enhancing selectivity in vesicles designed with integrated targeting moieties for sensing and drug delivery applications.

Indexed as

non-specific cellular interactionspolydiacetylenepoly(ethylene glycol)vesicles

Identifiers

PMID35321256
PMCPMC8936729

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.