Evidence map›Paper›PMID 35320932›Full record

ArticleFrontiers in immunology2022

Epithelial Heat Shock Proteins Mediate the Protective Effects of

Hao-Yu Liu, Fang Gu, Cuipeng Zhu, Long Yuan, Chuyang Zhu, Miaonan Zhu, Jiacheng Yao, Ping Hu, Yunzeng Zhang, Johan Dicksved and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The Role of ProbioticsInternational journal of molecular sciences · 2026
    Review
  5. Article
  6. Antioxidant and Anti-Inflammatory Activities of Probiotic Strains.International journal of molecular sciences · 2026
    Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. ProbioticAntioxidants (Basel, Switzerland) · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Hao-Yu LiuCollege of Animal Science and Technology, Yangzhou University, Yangzhou, China.
Fang GuCollege of Animal Science and Technology, Yangzhou University, Yangzhou, China.
Cuipeng ZhuCollege of Animal Science and Technology, Yangzhou University, Yangzhou, China.
Long YuanCollege of Animal Science and Technology, Yangzhou University, Yangzhou, China.
Chuyang ZhuCollege of Animal Science and Technology, Yangzhou University, Yangzhou, China.
Miaonan ZhuCollege of Animal Science and Technology, Yangzhou University, Yangzhou, China.
Jiacheng YaoCollege of Animal Science and Technology, Yangzhou University, Yangzhou, China.
Ping HuCollege of Animal Science and Technology, Yangzhou University, Yangzhou, China.
Yunzeng ZhangJiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China.
Johan DicksvedDepartment of Animal Nutrition and Management, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Wenbin BaoCollege of Animal Science and Technology, Yangzhou University, Yangzhou, China.
Demin CaiCollege of Animal Science and Technology, Yangzhou University, Yangzhou, China.
Yangzhou University · CNSwedish University of Agricultural Sciences · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Defects in gut barrier function are implicated in gastrointestinal (GI) disorders like inflammatory bowel disease (IBD), as well as in systemic inflammation. With the increasing incidence of IBD worldwide, more attention should be paid to dietary interventions and therapeutics with the potential to boost the natural defense mechanisms of gut epithelial cells. The current study aimed to investigate the protective effects of

Indexed as

ColitisInflammatory Bowel DiseasesLimosilactobacillus reuteriAnimalsDextran SulfateHeat-Shock ProteinsMiceRNA, Ribosomal, 16STight Junction ProteinsTumor Necrosis Factor-alphaDextran SulfateHeat-Shock ProteinsRNA, Ribosomal, 16STight Junction ProteinsTumor Necrosis Factor-alphabarrier functiongut microbiotaheat shock proteinsinflammatory bowel diseaseprobiotics

Identifiers

PMID35320932
PMCPMC8934773
OpenAlexW4221071814

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.