ArticleAging clinical and experimental research2022
Could neutrophil-to-lymphocyte ratio predict mortality in community-dwelling older people with delirium superimposed on dementia?
Article in Aging clinical and experimental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Delirium among older adults living at home: a systematic review of prevalence, incidence, and risk factors.The British journal of general practice : the journal of the Royal College of General Practitioners · 2025Pooled it
- Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio as prognostic predictors for delirium in critically ill patients: a systematic review and meta-analysis.BMC anesthesiology · 2023Pooled it
- The interrelationship between multiple long-term conditions (MLTC) and delirium: a scoping review.Age and ageing · 2024Article
- May the prognostic nutritional index (PNI) play a role in predicting age-related macular degeneration?International ophthalmology · 2024Observational
- Relationship of neutrophil/lymphocyte ratio with cerebral small vessel disease and its common imaging markers.Immunity, inflammation and disease · 2024Article
- A Novel Nomogram Developed Based on Preoperative Immune Inflammation-Related Indicators for the Prediction of Postoperative Delirium Risk in Elderly Hip Fracture Cases: A Single-Center Retrospective Cohort Study.Journal of inflammation research · 2024Article
- Association of drug burden index with delirium in community-dwelling older adults with dementia: a longitudinal observational study.International journal of clinical pharmacy · 2023Observational
- Efficacy of Neutrophil-to-Lymphocyte Ratio for Cancer-Specific Survival in Elderly Patients with Localized Colon Cancer: A Single Center Propensity Score-Matched Analysis.Clinical and experimental gastroenterology · 2023Article
- The Potential Value of Systemic Inflammation Response Index on Delirium After Hip Arthroplasty Surgery in Older Patients: A Retrospective Study.International journal of general medicine · 2023Article
- Identification of risk factors for 1-year mortality among critically ill older adults with hip fractures surgery: A single medical center retrospective study.Frontiers in surgery · 2022Article
- Lymphocyte-albumin-neutrophil ratio predicting short-term and long-term mortality risk in elderly patients with delirium: an analysis based on the MIMIC-IV database.Frontiers in neurologyArticle
- The prevalence and incidence of delirium superimposed on dementia in community settings: A systematic review and meta-analysis.Alzheimer's & dementia (Amsterdam, Netherlands)Review
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2 authors at 1 institution in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundDelirium superimposed on dementia (DSD) is associated with adverse outcomes in older adults. Nonetheless, little is known about the association between inflammatory markers and clinical outcomes of DSD.
aimsThis research investigated the predictive value of the neutrophil-to-lymphocyte ratio (NLR) for short- and long-term mortality among community-dwelling older adults with DSD.
methodsThis retrospective cohort study included 9755 older outpatients who were referred to a tertiary hospital between January 2010 and June 2021. All patients underwent a comprehensive geriatric assessment and routine laboratory tests. Delirium and dementia was diagnosed with the DSM-4 or DSM-5 criteria. We recorded information on mortality during 1 year following the delirium episode.
resultsAmong 615 patients with dementia, 170 (26.3%) had delirium. Patients with delirium were predominantly older, with higher Deyo-Charlson comorbidity index scores, lower general cognitive performance, lower functional capability, and higher anticholinergic burden compared to those without delirium. At the 1-year follow-up, the mortality rate of DSD was 29.3%. Multivariate analysis showed that NLR at admission was an independent predictor of 1-month mortality (HR = 1.03; 95% CI 1.00-1.05; p = 0.04) and 1-year mortality (HR = 1.02; 95% CI 1.01-1.05; p = 0.01) of DSD patients. DISCUSSION: NLR can predict prognosis in various diseases including cardiovascular disease, malignancies, and cerebrovascular disease, but as yet there is no similar prognostic measure in delirium. Moreover, recent previous studies demonstrated NLR is a potential marker for the prediction of delirium in older adults with different clinical settings. In the current study, we demonstrated that NLR is also a prognostic marker for DSD.
conclusionsNLR could be useful marker for predicting short- and long-term mortality in patients with DSD. However, further studies are needed to validate these findings.
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