Evidence map›Paper›PMID 35320732›Full record

ArticleDevelopmental cell2022

Cellular heterogeneity of human fallopian tubes in normal and hydrosalpinx disease states identified using scRNA-seq.

Nicole D Ulrich, Yu-Chi Shen, Qianyi Ma, Kun Yang, D Ford Hannum, Andrea Jones, Jordan Machlin, John F Randolph, Yolanda R Smith, Samantha B Schon and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 67 citations in OpenAlex.

  1. Article
  2. Review
  3. celltypeEnrich: a consensus-based scRNA-seq cluster annotation tool.bioRxiv : the preprint server for biology · 2026
    Article
  4. Review
  5. Article
  6. Tubal epithelial alterations: evolving concepts.Journal of gynecologic oncology · 2026
    Review
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  8. Article
  9. Review
  10. Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Nicole D UlrichDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.
Yu-Chi ShenDepartment of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
Qianyi MaDepartment of Human Genetics, University of Michigan, Ann Arbor, MI, USA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Kun YangDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.
D Ford HannumDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Andrea JonesDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Jordan MachlinDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
John F RandolphDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.
Yolanda R SmithDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.
Samantha B SchonDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.
Ariella ShikanovDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Erica E MarshDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.
Richard LiebermanDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Stephen J GurczynskiDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA.
Bethany B MooreDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Jun Z LiDepartment of Human Genetics, University of Michigan, Ann Arbor, MI, USA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA. Electronic address: junzli@med.umich.edu.
Sue HammoudDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA; Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI, USA; Department of Urology, University of Michigan, Ann Arbor, MI, USA. Electronic address: hammou@med.umich.edu.
University of Michigan–Ann Arbor · US

Funding

CELLULAR AND MOLECULAR BIOLOGY AT MICHIGANT32GM007315 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PUTHENVEEDU, MANOJKUMAR A · 1985 to 2021
$12.8M
Immunobiology of Lung Injury and FibrosisR35HL144481 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOORE, BETHANY B. · 2019 to 2024
$5.2M
Training Program in BioinformaticsT32GM070449 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ATHEY, BRIAN DAVID, BURMEISTER, MARGIT · 2005 to 2020
$3.6M
Contributions of Sperm Chromatin to development: A Myth or Reality?DP2HD091949 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAMMOUD, SAHER SUE · 2016 to 2016
$2.3M
Career Training in Reproductive BiologyT32HD079342 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Suzanne M MOENTER · 2014 to 2026
$2.3M
Comprehensive mapping of mouse testis cell types and spermatogenic stages by single-cell RNA sequencingR21HD090371 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAMMOUD, SAHER SUE · 2018 to 2019
$444k
Supplement Andrea JonesF31HD106626 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JONES, ANDREA · 2021 to 2023
$111k
NHLBI NIH HHS R35 HL144481NICHD NIH HHS DP2 HD091949NICHD NIH HHS F31 HD106626NICHD NIH HHS R21 HD090371NICHD NIH HHS T32 HD079342NIGMS NIH HHS T32 GM007315NIGMS NIH HHS T32 GM070449
6 · The paper itself

Abstract

Fallopian tube (FT) homeostasis requires dynamic regulation of heterogeneous cell populations and is disrupted in infertility and ovarian cancer. Here, we applied single-cell RNA-seq to profile 59,738 FT cells from four healthy, pre-menopausal subjects. The resulting cell atlas contains 12 major cell types representing epithelial, stromal, and immune compartments. Re-clustering of epithelial cells identified four ciliated and six non-ciliated secretory epithelial subtypes, two of which represent potential progenitor pools: one leading to mature secretory cells and the other contributing to either ciliated cells or one of the stromal cell types. To understand how FT cell numbers and states change in a disease state, we analyzed 17,798 cells from two hydrosalpinx samples and observed shifts in epithelial and stromal populations and cell-type-specific changes in extracellular matrix and TGF-β signaling; this underscores fibrosis pathophysiology. This resource is expected to facilitate future studies aimed at expanding understanding of fallopian tube homeostasis in normal development and disease.

Indexed as

Fallopian TubesOvarian NeoplasmsEpithelial CellsFemaleHumansSingle-Cell AnalysisEMTfallopian tubefemale infertilityhydrosalpinxovarian cancerprogenitor cellssingle-cell RNA-seqstem cell

Identifiers

PMID35320732
PMCPMC9007916
OpenAlexW4220882609

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.