ArticleCell reports2022
Coupling between DNA replication, segregation, and the onset of constriction in Escherichia coli.
Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Mechanism of persister formation in response to nitrogen starvation.Nature communications · 2026Article
- Emergent Homeostasis and Degeneracy From Multi-Dimensional Attractors.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Maintenance of cytoplasmic and membrane densities shapes cellular geometry in Escherichia coli.Nature communications · 2025Article
- The role of active mRNA-ribosome dynamics and closing constriction in daughter chromosome separation inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Nonequilibrium polysome dynamics promote chromosome segregation and its coupling to cell growth ineLife · 2025Article
- Nonequilibrium polysome dynamics promote chromosome segregation and its coupling to cell growth inbioRxiv : the preprint server for biology · 2025Article
- Article
- Spatio-temporal organization of theEcoSal Plus · 2024Review
- Determining the rate-limiting processes for cell division in Escherichia coli.Nature communications · 2024Article
- The "weaken-fill-repair" model for cell budding: Linking cell wall biosynthesis with mechanics.iScience · 2024Article
- Direct single-cell observation of a keyScience advances · 2024Article
- Near-infrared co-illumination of fluorescent proteins reduces photobleaching and phototoxicity.Nature biotechnology · 2024Article
- Mechanisms of cell size regulation in slow-growing Escherichia coli cells: discriminating models beyond the adder.NPJ systems biology and applications · 2024Article
- Rearing condition influences gene expression in postlarval American lobster (Homarus americanus).PloS one · 2024Article
- Mid-cell migration of the chromosomal terminus is coupled to origin segregation in Escherichia coli.Nature communications · 2023Article
- Creating Polyploid Escherichia Coli and Its Application in Efficient L-Threonine Production.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Bacterial cell-size changes resulting from altering the relative expression of Min proteins.Nature communications · 2023Article
- Recollections of a Helmstetter Disciple.Life (Basel, Switzerland) · 2023Review
- The Bacterial Nucleoid: From Electron Microscopy to Polymer Physics-A Personal Recollection.Life (Basel, Switzerland) · 2023Review
- Using conditional independence tests to elucidate causal links in cell cycle regulation inProceedings of the National Academy of Sciences of the United States of America · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Escherichia coli cell cycle features two critical cell-cycle checkpoints: initiation of replication and the onset of constriction. While the initiation of DNA replication has been extensively studied, it is less clear what triggers the onset of constriction and when exactly it occurs during the cell cycle. Here, using high-throughput fluorescence microscopy in microfluidic devices, we determine the timing for the onset of constriction relative to the replication cycle in different growth rates. Our single-cell data and modeling indicate that the initiation of constriction is coupled to replication-related processes in slow growth conditions. Furthermore, our data suggest that this coupling involves the mid-cell chromosome blocking the onset of constriction via some form of nucleoid occlusion occurring independently of SlmA and the Ter linkage proteins. This work highlights the coupling between replication and division cycles and brings up a new nucleoid mediated control mechanism in E. coli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.