ArticleCell reports2022
A 3D transcriptomics atlas of the mouse nose sheds light on the anatomical logic of smell.
Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Article
- A spatial code governs olfactory receptor choice and aligns sensory maps in the nose and brain.Cell · 2026Article
- CTFacTomo: Reconstructing 3D spatial structures of RNA tomography transcriptomes by collapsed tensor factorization.PLoS computational biology · 2026Article
- The neurexin gene family regulates olfactory glomerular formation.Cell reports · 2025Article
- Wider Than the Sky: An Alternative to "Mapping" the World Onto the Brain.The European journal of neuroscience · 2025Article
- Rapid Dissection and Dissociation of the Mouse Olfactory Epithelium for Single-Nucleus Suspensions.Journal of visualized experiments : JoVE · 2025Article
- A common mechanism of singular gene choice is revealed by broadly expressed odorant receptor transgenes within the olfactory epithelium.Cell reports · 2025Article
- Exploring the latent space of transcriptomic data with topic modeling.NAR genomics and bioinformatics · 2025Article
- Genomic snowflakes: how the uniqueness of DNA folding allows us to smell the chemical universe.Current opinion in genetics & development · 2025Review
- tomoseqr: A Bioconductor package for spatial reconstruction and visualization of 3D gene expression patterns based on RNA tomography.PloS one · 2025Article
- Spatial Transcriptomics, Proteomics, and Epigenomics as Tools in Tissue Engineering and Regenerative Medicine.Bioengineering (Basel, Switzerland) · 2024Article
- Transcriptional priming and chromatin regulation during stochastic cell fate specification.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Epigenetic programming of stochastic olfactory receptor choice.Genesis (New York, N.Y. : 2000) · 2024Review
- Connectivity and molecular profiles of Foxp2- and Dbx1-lineage neurons in the accessory olfactory bulb and medial amygdala.The Journal of comparative neurology · 2024Article
- Article
- Domestic cat nose functions as a highly efficient coiled parallel gas chromatograph.PLoS computational biology · 2023Article
- Tissue clearing and 3D reconstruction of digitized, serially sectioned slides provide novel insights into pancreatic cancer.Med (New York, N.Y.) · 2023Review
- Genome-Wide RNA Tomography in the Mouse Whole Olfactory Mucosa.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Target-Captured mRNA from Murine Olfactory Bulb.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Modulation of the NO-cGMP pathway has no effect on olfactory responses in theFrontiers in cellular neuroscience · 2023Article
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Authors and funding
18 authors at 6 institutions in 6 countries.
Funding
Abstract
The sense of smell helps us navigate the environment, but its molecular architecture and underlying logic remain understudied. The spatial location of odorant receptor genes (Olfrs) in the nose is thought to be independent of the structural diversity of the odorants they detect. Using spatial transcriptomics, we create a genome-wide 3D atlas of the mouse olfactory mucosa (OM). Topographic maps of genes differentially expressed in space reveal that both Olfrs and non-Olfrs are distributed in a continuous and overlapping fashion over at least five broad zones in the OM. The spatial locations of Olfrs correlate with the mucus solubility of the odorants they recognize, providing direct evidence for the chromatographic theory of olfaction. This resource resolves the molecular architecture of the mouse OM and will inform future studies on mechanisms underlying Olfr gene choice, axonal pathfinding, patterning of the nervous system, and basic logic for the peripheral representation of smell.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.