ArticleImmunity2022
Single-cell multiomics reveals persistence of HIV-1 in expanded cytotoxic T cell clones.
Open access · greenAbstract read
In one paragraph
Article in Immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.
0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed
10.8field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
118 citing papers in PubMed, 161 citations in OpenAlex.
- Trial
- Natural killers blast HIV reservoir landscape.Nature immunology · 2026Article
- Article
- Single-cell profiling reveals IFI44L as a central regulator of immune dysregulation in high HIV viral load.Medical microbiology and immunology · 2026Article
- The Rectal Mucosal Myeloid Niche in HIV-1 Persistence: Reservoir Support, Viral Sequestration, and Therapeutic Opportunities.Viruses · 2026Review
- Central nervous system B cell multiomics reveals a legacy of immune dysregulation in long-term treated HIV infection.Science advances · 2026Article
- Three immunoregulatory signatures define non-productive HIV infection in stem cell memory CD4Nature communications · 2026Article
- Multi-omics and artificial intelligence for precision drug discovery and potential clinical applications.Signal transduction and targeted therapy · 2026Review
- Is the molecular microenvironment of the latent HIV reservoir predictable using deep learning approaches?Journal of virology · 2026Review
- Article
- Article
- Clonal dynamics of HIV-infected and uninfected T cells.EBioMedicine · 2026Article
- Three immunoregulatory signatures define non-productive HIV infection in CD4bioRxiv : the preprint server for biology · 2026Article
- Cytomegalovirus in HIV: A Modifiable Driver of Inflammation, Frailty, and Aging.Current HIV/AIDS reports · 2026Review
- Excessive reactive oxygen species attenuated IL-17 production in CD161Cell communication and signaling : CCS · 2026Article
- Review
- Cytotoxic CD4Signal transduction and targeted therapy · 2026Review
- HIV-seq reveals gene expression differences between HIV-transcribing cells from viremic and suppressed people with HIV.Nature communications · 2026Article
- Transcription of HIV-1 is heterogenous among authentic latent CD4+ T cell clones.The Journal of experimental medicine · 2026Article
- Single-cell capture of on-ART SIV transcription reveals TGF-β-mediated metabolic control of viral latency.JCI insight · 2026Article
58 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 6 institutions in 2 countries.
Jack A ColloraDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA.
Runxia LiuDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA.
Delia Pinto-SantiniVaccine and Infectious Disease, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Neal RavindraDepartment of Internal Medicine (Cardiology), Yale School of Medicine, New Haven, CT 06520, USA; Department of Computer Science, Yale University, New Haven, CT 06520, USA.
Carmela GanozaAsociación Civil Impacta Salud y Educación, Lima, 15063, Perú.
Javier R LamaAsociación Civil Impacta Salud y Educación, Lima, 15063, Perú.
Ricardo AlfaroCentro de Investigaciones Tecnológicas Biomédicas y Medioambientales (CITBM), Lima, 07006, Perú.
Jennifer ChiarellaDepartment of Neurology, Yale University School of Medicine, New Haven, CT 06519, USA.
Serena SpudichDepartment of Neurology, Yale University School of Medicine, New Haven, CT 06519, USA.
Karam MounzerPhiladelphia FIGHT Community Health Centers, Philadelphia, PA 19107, USA.
Pablo TebasDepartment of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Luis J MontanerThe Wistar Institute, Philadelphia, PA 19104, USA.
David van DijkDepartment of Internal Medicine (Cardiology), Yale School of Medicine, New Haven, CT 06520, USA; Department of Computer Science, Yale University, New Haven, CT 06520, USA.
Ann DuerrVaccine and Infectious Disease, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Ya-Chi HoDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA. Electronic address: ya-chi.ho@yale.edu.
Yale University · USAsociación Civil Impacta Salud y Educación · PEFred Hutch Cancer Center · USPhiladelphia Fight · USThe Wistar Institute · USUniversity of Pennsylvania · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MBEAT-HIV: Delaney Collaboratory to Cure HIV-1 Infection by Combination ImmunotherapyUM1AI164570 · NIAID · WISTAR INSTITUTE · PI Luis J Montaner, James L. Riley · 2021 to 2026
$34.7MREACH: Research Enterprise to Advance a Cure for HIVUM1AI164565 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Marina Caskey, R. Brad Jones · 2021 to 2026
$32.9MFirst-in-human study of two anti-SARS CoV-2 antibodies in health volunteersUM1AI126620 · NIAID · WISTAR INSTITUTE · PI MONTANER, LUIS J, RILEY, JAMES L. · 2016 to 2021
$24.5MThe Y-SCORCH Data Generation Center at Yale for Single-Cell Opioid Responses in the Context of HIVUM1DA051410 · NIDA · YALE UNIVERSITY · PI GERSTEIN, MARK BENDER, KLUGER, YUVAL · 2020 to 2025
$15.3MVirus TransmissionP50AI150464 · NIAID · UNIVERSITY OF UTAH · PI SUNDQUIST, WESLEY I. · 2019 to 2021
$14.9MM-SCORCH: Methamphetamine use disorder data generation center for Single Cell Opioid Responses in the Context of HIVU01DA053628 · NIDA · YALE UNIVERSITY · PI HO, YA-CHI, SESTAN, NENAD · 2021 to 2025
$9.5MModulating the Impact of Critical Events in Early HIV Infection: Effect of Early ART Initiation and Alcohol UseR01DA040532 · NIDA · FRED HUTCHINSON CANCER RESEARCH CENTER · PI DUERR, ANN C · 2015 to 2019
$8.0MHIV Testing and Treatment to Prevent Onward HIV Transmission among High-risk MSMR01DA032106 · NIDA · FRED HUTCHINSON CANCER RESEARCH CENTER · PI DUERR, ANN C · 2011 to 2015
$6.6MThe HUSH complex in HIV-1 latencyR37AI147868 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI JEREMY LUBAN · 2019 to 2026
$6.4MCNS Viral Persistence and Neuropsychiatric Perturbations in HIV: Single cell and Molecular InterrogationR01MH125737 · NIMH · YALE UNIVERSITY · PI CYKTOR, JOSHUA CHARLES, SPUDICH, SERENA S · 2021 to 2025
$5.4MRole of clonal expansion in HIV-1 persistenceR01AI141009 · NIAID · YALE UNIVERSITY · PI Ya-Chi Ho · 2018 to 2026
$5.3MNCATS NIH HHS UL1 TR001863NIAID NIH HHS P50 AI150464NIAID NIH HHS R01 AI141009NIAID NIH HHS R01 AI145164NIAID NIH HHS R37 AI147868NIAID NIH HHS T32 AI055403NIAID NIH HHS UM1 AI126620NIAID NIH HHS UM1 AI164565NIAID NIH HHS UM1 AI164570NIDA NIH HHS R01 DA032106NIDA NIH HHS R01 DA040532NIDA NIH HHS R01 DA051906NIDA NIH HHS R33 DA047037NIDA NIH HHS R61 DA047037NIDA NIH HHS U01 DA053628NIDA NIH HHS UM1 DA051410NIGMS NIH HHS R35 GM143072NIMH NIH HHS R01 MH125737
Abstract
Understanding the drivers and markers of clonally expanding HIV-1-infected CD4
Indexed as
HIV-1HIV InfectionsCD4-Positive T-LymphocytesClone CellsHumansRNAViremiaRNAantigen stimulationclonal expansioncytotoxic CD4(+) T lymphocytesgranzyme BHIV-1-induced immune dysfunctionHIV-1 latent reservoirHIV-1 persistencesingle-cell RNA-seqT cell expansion dynamicsTNF response
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.