Evidence map›Paper›PMID 35320552›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

Evaluating Therapeutic Activity of Galectin-1 in Sarcolemma Repair of Skeletal Muscle.

Mary L Vallecillo-Zúniga, Matthew Rathgeber, Daniel Poulson, Braden Kartchner, Jacob Luddington, Hailie Gill, Spencer Hayes, Matthew Teynor, Caleb S Stowell, Connie M Arthur and 2 more

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Mary L Vallecillo-ZúnigaDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA.
Matthew RathgeberDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA.
Daniel PoulsonDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA.
Braden KartchnerDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA.
Jacob LuddingtonDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA.
Hailie GillDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA.
Spencer HayesDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA.
Matthew TeynorDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA.
Caleb S StowellDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA.
Connie M ArthurJoint Program in Transfusion Medicine, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Sean R StowellJoint Program in Transfusion Medicine, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Pam M Van RyDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA. pvanry@chem.byu.edu.
Brigham Young University · USHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Galectin-1 is a small (14.5 kDa) multifunctional protein with cell-cell and cell-ECM adhesion due to interactions with the carbohydrate recognition domain (CRD). In two types of muscular dystrophies, this lectin protein has shown therapeutic properties, including positive regulation of skeletal muscle differentiation and regeneration. Both Duchenne and limb-girdle muscular dystrophy 2B (LGMD2B) are subtypes of muscular dystrophies characterized by deficient membrane repair, muscle weakness, and eventual loss of ambulation. This chapter explains confocal techniques such as laser injury, calcium imaging, and galectin-1 localization to examine the effects of galectin-1 on membrane repair in injured LGMD2B models.

Indexed as

Galectin 1Muscular Dystrophies, Limb-GirdleSarcolemmaHumansMuscle, SkeletalGalectin 1Galectin-1LGMD2BLocalizationMembrane repairMuscular dystrophyProtein labelingSarcolemma

Identifiers

PMID35320552
OpenAlexW4221033393

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.