Evidence map›Paper›PMID 35320487›Full record

Observational studyIrish journal of medical science2023

Association of androgenetic alopecia with a more severe form of COVID-19 infection.

Dunja Veskovic, Tatjana Ros, Tijana Icin, Kristina Stepanovic, Nebojsa Janjic, Dusan Kuljancic, Sonja Sedlarevic, Dmitar Vlahovic

Open access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Irish journal of medical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Dunja VeskovicMedical Faculty, University of Novi Sad, Hajduk Veljkova 3 21000, Novi Sad, Serbia. dunja.veskovic@mf.uns.ac.rs.
Tatjana RosMedical Faculty, University of Novi Sad, Hajduk Veljkova 3 21000, Novi Sad, Serbia.
Tijana IcinMedical Faculty, University of Novi Sad, Hajduk Veljkova 3 21000, Novi Sad, Serbia.
Kristina StepanovicMedical Faculty, University of Novi Sad, Hajduk Veljkova 3 21000, Novi Sad, Serbia.
Nebojsa JanjicMedical Faculty, University of Novi Sad, Hajduk Veljkova 3 21000, Novi Sad, Serbia.
Dusan KuljancicMedical Faculty, University of Novi Sad, Hajduk Veljkova 3 21000, Novi Sad, Serbia.
Sonja SedlarevicMedical Faculty, University of Novi Sad, Hajduk Veljkova 3 21000, Novi Sad, Serbia.
Dmitar VlahovicMedical Faculty, University of Novi Sad, Hajduk Veljkova 3 21000, Novi Sad, Serbia.
University of Novi Sad · RSKlinički centar Vojvodine · RS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIndividual susceptibility to develop acute respiratory distress syndrome is related to age and most frequent comorbidities. So far, it is known that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily infects the type II pneumocytes in humans, with the help of transmembrane serine protease type 2 (TMPRSS2). Up to now, the only known transcriptional promoters of genes coding TMPRSS2 are androgenic. Theoretically, the elevated level of androgens or androgen receptors would lead to a higher expression of TMPRSS2 and a higher level of viremia as a consequence.

aimThe aim of our research was to indirectly investigate if the severity of SARS-CoV-2 infection is dependent on the expression of androgen receptors.

methodsThis observational study analysed male patients hospitalized for SARS-CoV-2 infection with respect to the length of hospitalisation, the outcome of the disease, the type of necessary oxygen support and the presence of comorbidities and hairiness. In hairiness estimation, we used an adapted version of the Hamilton-Norwood scale and the presence of the Gabrin sign.

resultsIn total, 208 patients were enrolled in the study. There were statistically significant differences comparing the average age of patients with the different types of alopecia when groups were divided according to the presence of the Gabrin sign (t = 4.958, p > 0.01). The outcomes and the type of needed minimal oxygen support, compared with the type of alopecia in the case of Gabrin + / - classification showed a statistically significant difference in the outcome of the disease (p = 0.027). There were no statistically significant differences in the distribution of comorbidities among alopecia groups, but hypertension was related to poor COVID-19 prognosis.

conclusionOur findings suggest that the Gabrin sign and hypertension are related to a poor COVID-19 prognosis.

Indexed as

COVID-19HypertensionAlopeciaAndrogensHumansMaleReceptors, AndrogenSARS-CoV-2AndrogensReceptors, AndrogenAndrogenetic alopeciaAndrogen receptorsGabrin signSARS-CoV-2Transmembrane serine protease 2

Identifiers

PMID35320487
PMCPMC8942051
OpenAlexW4220758998

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.