Evidence map›Paper›PMID 35320449›Full record

ArticleInternational journal of clinical oncology2022

Risk of first onset of colorectal cancer associated with alcohol consumption in Lynch syndrome: a multicenter cohort study.

Kenji Fujiyoshi, Tomoya Sudo, Fumihiko Fujita, Akiko Chino, Kiwamu Akagi, Akinari Takao, Masayoshi Yamada, Kohji Tanakaya, Hideyuki Ishida, Koji Komori and 9 more

Erratum issuedAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in International journal of clinical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 15 institutions in 1 country.

Kenji FujiyoshiDepartment of Surgery, Kurume University, 67 Asahi-machi, Kurume, Fukuoka, 830-0037, Japan. fujiyoshi_kenji@med.kurume-u.ac.jp.ORCID http://orcid.org/0000-0002-0310-5807
Tomoya SudoDepartment of Surgery, Kurume University, 67 Asahi-machi, Kurume, Fukuoka, 830-0037, Japan.
Fumihiko FujitaDepartment of Surgery, Kurume University, 67 Asahi-machi, Kurume, Fukuoka, 830-0037, Japan.
Akiko ChinoThe Committee of Hereditary Colorectal Cancer of the Japanese Society for Cancer of the Colon and Rectum, Tokyo, Japan.
Kiwamu AkagiThe Committee of Hereditary Colorectal Cancer of the Japanese Society for Cancer of the Colon and Rectum, Tokyo, Japan.
Akinari TakaoThe Committee of Hereditary Colorectal Cancer of the Japanese Society for Cancer of the Colon and Rectum, Tokyo, Japan.
Masayoshi YamadaThe Committee of Hereditary Colorectal Cancer of the Japanese Society for Cancer of the Colon and Rectum, Tokyo, Japan.
Kohji TanakayaThe Committee of Hereditary Colorectal Cancer of the Japanese Society for Cancer of the Colon and Rectum, Tokyo, Japan.
Hideyuki IshidaThe Committee of Hereditary Colorectal Cancer of the Japanese Society for Cancer of the Colon and Rectum, Tokyo, Japan.
Koji KomoriThe Committee of Hereditary Colorectal Cancer of the Japanese Society for Cancer of the Colon and Rectum, Tokyo, Japan.
Soichiro IshiharaThe Committee of Hereditary Colorectal Cancer of the Japanese Society for Cancer of the Colon and Rectum, Tokyo, Japan.
Masashi MiguchiThe Committee of Hereditary Colorectal Cancer of the Japanese Society for Cancer of the Colon and Rectum, Tokyo, Japan.
Keiji HirataThe Committee of Hereditary Colorectal Cancer of the Japanese Society for Cancer of the Colon and Rectum, Tokyo, Japan.
Yasuyuki MiyakuraThe Committee of Hereditary Colorectal Cancer of the Japanese Society for Cancer of the Colon and Rectum, Tokyo, Japan.
Toshiaki IshikawaThe Committee of Hereditary Colorectal Cancer of the Japanese Society for Cancer of the Colon and Rectum, Tokyo, Japan.
Tatsuro YamaguchiThe Committee of Hereditary Colorectal Cancer of the Japanese Society for Cancer of the Colon and Rectum, Tokyo, Japan.
Naohiro TomitaThe Committee of Hereditary Colorectal Cancer of the Japanese Society for Cancer of the Colon and Rectum, Tokyo, Japan.
Yoichi AjiokaThe Japanese Society for Cancer of the Colon and Rectum, Tokyo, Japan.
Kenichi SugiharaTokyo Medical and Dental University, Tokyo, Japan.
Kurume University · JPTokyo Medical and Dental University · JPTokyo Metropolitan Komagome Hospital · JPAichi Cancer Center · JPHiroshima Prefectural Hospital · JPIwakuni Medical Center · JPJapanese Foundation For Cancer Research · JPJichi Medical University · JPNational Cancer Centre Japan · JPNiigata University · JPSaitama Cancer Center · JPSocial Insurance Saitama Chuo Hospital · JPThe University of Tokyo · JPToyonaka Municipal Hospital · JPUniversity of Occupational and Environmental Health Japan · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundComplex interactions among endogenous and exogenous factors influence the incidence of colorectal cancer (CRC). Germline mutations in mismatch repair (MMR) genes causing Lynch syndrome (LS) are major endogenous factors. The exogenous factor, alcohol consumption, is potentially associated with CRC incidence among patients with LS. However, insufficient data are available to determine whether alcohol consumption influences the time of the first onset of CRC associated with sex, MMR gene mutations, and anatomical tumor site.

methodsAmong 316 patients with LS identified in a Japanese LS cohort, we included 288 with data on age, sex, proband status, alcohol status, smoking status, tumor location, and MMR gene mutations. Multivariable analysis assessed the association of alcohol consumption with earlier onset of the first CRC.

resultsEver drinkers were associated with higher risk of the first onset of CRC than never drinkers (HR 1.54, 95%CI 1.14-2.07, P = 0.004). The association of the first onset of CRC with alcohol consumption was stronger in men, carriers of pathogenic MLH1 and MSH2 mutations (vs those with pathogenic MSH6, PMS2 and EPCAM mutations), and tumors in the proximal colon cancer (vs distal colon and rectal cancer).

conclusionsAlcohol consumption was associated with earlier onset of the first CRC in Japanese LS cohort. The association was stronger in men, carriers of pathogenic MLH1 and MSH2 mutations, and tumors located in the proximal colon. Our findings illuminate the mechanism of LS-associated carcinogenesis and serve as a recommendation for discontinuing or ceasing alcohol consumption.

Indexed as

Colorectal NeoplasmsColorectal Neoplasms, Hereditary NonpolyposisAlcohol DrinkingCohort StudiesDNA Mismatch RepairHumansMaleMutS Homolog 2 ProteinMutS Homolog 2 ProteinAdenocarcinomaDrinkingLifestyleRisk factor

Identifiers

PMID35320449
OpenAlexW4221096844

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.