Evidence map›Paper›PMID 35320316›Full record

ArticlePloS one2022

Knowledge of hepatitis C and awareness of reinfection risk among people who successfully completed direct acting antiviral therapy.

Kiana Yazdani, Katerina Dolguikh, Wendy Zhang, Sara Shayegi-Nik, Jessica Ly, Shaughna Cooper, Jason Trigg, Sophia Bartlett, Rolando Barrios, Julio S G Montaner and 1 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Article
  3. Clinical andInfectious disorders drug targets · 2025
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Kiana YazdaniBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.ORCID 0000-0003-1929-729X
Katerina DolguikhBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.ORCID 0000-0001-8241-1564
Wendy ZhangBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Sara Shayegi-NikBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Jessica LyBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Shaughna CooperBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Jason TriggBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.ORCID 0000-0002-7815-0725
Sophia BartlettSchool of Population and Public Health, University of British Columbia, Vancouver, Canada.ORCID 0000-0003-0699-2250
Rolando BarriosBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Julio S G MontanerBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Kate SaltersBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
AIDS Vancouver · CAUniversity of British Columbia · CASimon Fraser University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHepatitis C virus (HCV) education may be changing following the simplification of HCV treatment and emergence of direct acting antiviral (DAA). We aimed to characterize HCV knowledge among people who recently completed DAA therapy.

methodsThe Per-SVR (Preservation of Sustained Virologic Response) is a prospective cohort of patients who achieved a sustained virologic response upon successful completion of DAA therapy. The per-SVR study provided the sampling frame of participants who completed a psychometrically validated 19-item HCV knowledge scale at cohort entry (n = 227). To score the questionnaire, for each correct response one point was awarded, with no point for incorrect response. We assessed mean HCV knowledge score in the overall sample and mutually exclusive populations: people who inject drug (PWID) (n = 71); people with co-occurring HIV (n = 23); PWID and co-occurring HIV (n = 29), and others (n = 104) Using a latent class analysis based on distal outcome, we identified unobserved subgroups and assessed HCV knowledge amongst them.

resultsTotal mean (SD) percent of correct responses were 83 (11) in the overall sample; 83 (10) in PWID; 79 (12) in people with co-occurring HIV; 81 (10) in PWID and co-occurring HIV, and 84 (11) in rest of the sample Three latent groups were identified: baby boomers who ever experienced homelessness (n = 126); women sex workers who ever experienced homelessness (n = 68); men who inject drug, ever experienced homelessness and had ever diagnosis of mental health disorders (n = 18). Mean percent of correct responses were 85 (8), 82 (11), 85 (10), in latent class 1, 2, and 3, respectively.

conclusionPatients successfully treated with DAAs had a high HCV knowledge. High knowledge and awareness of reinfection among complex patient groups often facing barriers to HCV care is encouraging and emphasizes the positive outcomes of universal access to treatment.

Indexed as

Hepatitis CHepatitis C, ChronicHIV InfectionsSubstance Abuse, IntravenousAntiviral AgentsFemaleHepacivirusHumansMaleProspective StudiesReinfectionAntiviral Agents

Identifiers

PMID35320316
PMCPMC8942206
OpenAlexW4221028030

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.