Evidence map›Paper›PMID 35320037›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Prediction-error neurons in circuits with multiple neuron types: Formation, refinement, and functional implications.

Loreen Hertäg, Claudia Clopath

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

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  8. Increased Perceptual Reliability Reduces Membrane Potential Variability in Cortical Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
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  15. Learning predictive signals within a local recurrent circuit.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  16. Article
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  19. Layer-specific control of inhibition by NDNF interneurons.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Loreen HertägBioengineering Department, Imperial College London, London SW7 2AZ, United Kingdom.ORCID 0000-0001-7838-3361
Claudia ClopathBioengineering Department, Imperial College London, London SW7 2AZ, United Kingdom.ORCID 0000-0003-4507-8648

Funding

Wellcome Trust
6 · The paper itself

Abstract

SignificanceAn influential idea in neuroscience is that neural circuits do not only passively process sensory information but rather actively compare them with predictions thereof. A core element of this comparison is prediction-error neurons, the activity of which only changes upon mismatches between actual and predicted sensory stimuli. While it has been shown that these prediction-error neurons come in different variants, it is largely unresolved how they are simultaneously formed and shaped by highly interconnected neural networks. By using a computational model, we study the circuit-level mechanisms that give rise to different variants of prediction-error neurons. Our results shed light on the formation, refinement, and robustness of prediction-error circuits, an important step toward a better understanding of predictive processing.

Indexed as

Neural Networks, ComputerNeuronshomeostatic plasticityinhibitory interneuronsprediction-error neuronspredictive processingsensory coding

Identifiers

PMID35320037
PMCPMC9060484

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.