ArticleJournal of neurophysiology2022
Subthalamic deep brain stimulation of an anatomically detailed model of the human hyperdirect pathway.
Article in Journal of neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- In silico model of basal ganglia deep brain stimulation in Parkinson's disease captures range of effective parameters for pathological beta power suppression.PLoS computational biology · 2026Article
- Clinical utility of evoked potentials for programming subthalamic deep brain stimulation in Parkinsons disease.NPJ Parkinson's disease · 2026Review
- Joint Anatomical, Histological, and Imaging Investigation of the Midbrain Target Region for Superolateral Medial Forebrain Bundle Deep Brain Stimulation.Stereotactic and functional neurosurgery · 2025Article
- Neural pathway activation in the subthalamic region depends on stimulation polarity.Brain communications · 2025Article
- Prospective Connectomic-Based Deep Brain Stimulation Programming for Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2024Article
- A survey on integral equations for bioelectric modeling.Physics in medicine and biology · 2024Review
- Does Vestibular Motion Perception Correlate with Axonal Pathways Stimulated by Subthalamic Deep Brain Stimulation in Parkinson's Disease?Cerebellum (London, England) · 2024Article
- Coupled Activation of the Hyperdirect and Cerebellothalamic Pathways with Zona Incerta Deep Brain Stimulation.Movement disorders : official journal of the Movement Disorder Society · 2024Article
- Estimations of Charge Deposition Onto Convoluted Axon Surfaces Within Extracellular Electric Fields.IEEE transactions on bio-medical engineering · 2024Article
- Programming of subthalamic nucleus deep brain stimulation with hyperdirect pathway and corticospinal tract-guided parameter suggestions.Human brain mapping · 2023Article
- Influence of charges deposited on membranes of human hyperdirect pathway axons on depolarization during subthalamic deep brain stimulation.Journal of neural engineering · 2023Article
- DBS-evoked cortical responses index optimal contact orientations and motor outcomes in Parkinson's disease.NPJ Parkinson's disease · 2023Article
- Evolving characterization of the human hyperdirect pathway.Brain structure & function · 2023Review
- Myogenic and cortical evoked potentials vary as a function of stimulus pulse geometry delivered in the subthalamic nucleus of Parkinson's disease patients.Frontiers in neurology · 2023Article
- The impact of pulse timing on cortical and subthalamic nucleus deep brain stimulation evoked potentials.Frontiers in human neuroscience · 2022Article
- Comprehensive map of axonal pathway activation as a function of subthalamic deep brain stimulation location and parameter settings.Brain stimulationArticle
- Enabling electric field model of microscopically realistic brain.Brain stimulationArticle
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2 authors.
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Abstract
The motor hyperdirect pathway (HDP) is considered a key target in the treatment of Parkinson's disease with subthalamic deep brain stimulation (DBS). This hypothesis is partially derived from the association of HDP activation with evoked potentials (EPs) generated in the motor cortex and subthalamic nucleus (STN) after a DBS pulse. However, the biophysical details of how and when DBS-induced action potentials (APs) in HDP neurons reach their terminations in the cortex or STN remain unclear. Therefore, we used an anatomically detailed representation of the motor HDP, as well as the internal capsule (IC), in a model of human subthalamic DBS to explore AP activation and transmission in the HDP and IC. Our results show that small diameter HDP axons exhibited AP initiation in their subthalamic terminal arbor, which resulted in relatively long transmission latencies to cortex (∼3.5-8 ms). Alternatively, large diameter HDP axons were most likely to be directly activated in the capsular region, which resulted in short transmission times to the cortex (∼1-3 ms). However, those large diameter HDP antidromic APs would be indistinguishable from any other IC axons that were also activated by the stimulus. Conversely, DBS-induced APs in both small and large diameter HDP axons reached their synaptic boutons in the STN with similar timings, but both spanned a wide temporal range (∼0.5-5 ms). We also found that using anodic or bipolar stimulation helped to bias activation of the HDP over the IC. These computational results provide useful information for linking HDP activation with EP recordings in clinical experiments.
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