ArticleScience advances2022
Opposite effects of stress on effortful motivation in high and low anxiety are mediated by CRHR1 in the VTA.
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 41 citations in OpenAlex.
- Brain mitochondria as key drivers of cognition and behaviour.Nature reviews. Neuroscience · 2026Review
- Genetically informed dissection of multimodal brain aging and ten major psychiatric disorders.Molecular psychiatry · 2026Article
- Mitofusin-2 in ventral striatal D1 neurons regulates effort-based motivation through sex-specific mitochondrial-synaptic reprogramming.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Sustained hyperactivity of parasubthalamic nucleus by PACAP signaling mediates stress-induced anxiety.Molecular psychiatry · 2026Article
- Article
- Impact of brief maternal separation on rodent models of anergia induced by dopamine depletion: analysis in mice of both sexes during adulthood.Psychopharmacology · 2025Article
- Biopsychosocial correlates of resting and stress-reactive salivary GDF15: preliminary findings.Brain, behavior, and immunity · 2025Article
- Counterbalancing O-GlcNAcylation and STAT3 Phosphorylation in Ventral Tegmental Area Dopaminergic Neurons Mediates Behavioral Adaptations to Acute Restraint Stress.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Relationship between neuropsychiatric symptoms and social support in older adults with mild behavioral impairment: a moderated mediation model.Scientific reports · 2025Article
- Corticotropin-releasing hormone modulates NREM sleep consolidation through the thalamic reticular nucleus.Nature communications · 2025Article
- VTA-ACC dopaminergic circuit mediates trait anxiety-related observational learning of social avoidance in male mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Translating stress systems: corticotropin releasing factor, its receptors, and the dopamine system in nonhuman primate models.Genomic psychiatry : advancing science from genes to society · 2025Article
- Effects of repeated social stress on risk assessment behaviors and response to diazepam in the elevated plus maze in adult male rats.Behavioral neuroscience · 2025Article
- Reducing stress and alcohol-related behaviors by targeting D1-CRHR1 receptor interactions in the amygdala.Frontiers in pharmacology · 2025Article
- Differential Impact of Adolescent or Adult Stress on Behavior and Cortical Parvalbumin Interneurons and Perineuronal Nets in Male and Female Mice.The international journal of neuropsychopharmacology · 2024Article
- Brain Gene Regulatory Networks Coordinate Nest Construction in Birds.Molecular biology and evolution · 2024Article
- Effects of acute stress on reward processing: A comprehensive meta-analysis of rodent and human studies.Neurobiology of stress · 2024Review
- Hypothalamic CRF neurons facilitate brain reward function.Current biology : CB · 2024Article
- Hidden variables in stress neurobiology research.Trends in neurosciences · 2024Review
- Corticotropin-releasing factor and GABA in the ventral tegmental area modulate partner preference formation in male and female prairie voles (Frontiers in neuroscience · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Individuals frequently differ in their behavioral and cognitive responses to stress. However, whether motivation is differently affected by acute stress in different individuals remains to be established. By exploiting natural variation in trait anxiety in outbred Wistar rats, we show that acute stress facilitates effort-related motivation in low anxious animals, while dampening effort in high anxious ones. This model allowed us to address the mechanisms underlying acute stress-induced differences in motivated behavior. We show that CRHR1 expression levels in dopamine neurons of the ventral tegmental area (VTA)-a neuronal type implicated in the regulation of motivation-depend on animals' anxiety, and these differences in CRHR1 expression levels explain the divergent effects of stress on both effortful behavior and the functioning of mesolimbic DA neurons. These findings highlight CRHR1 in VTA DA neurons-whose levels vary with individuals' anxiety-as a switching mechanism determining whether acute stress facilitates or dampens motivation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.