Evidence map›Paper›PMID 35319832›Full record

Trial reportInternational forum of allergy & rhinology2022

Chitogel following endoscopic sinus surgery promotes a healthy microbiome and reduces postoperative infections.

Anna Megow, Yazeed Alsuliman, George Bouras, Martha Menberu, Erich Vyskocil, Sarah Vreugde, Peter-John Wormald

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International forum of allergy & rhinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Anna MegowDepartment of Surgery - Otolaryngology, Head and Neck Surgery, University of Adelaide, South Australia, Australia.ORCID 0000-0002-2034-4746
Yazeed AlsulimanDepartment of Surgery - Otolaryngology, Head and Neck Surgery, University of Adelaide, South Australia, Australia.
George BourasDepartment of Surgery - Otolaryngology, Head and Neck Surgery, University of Adelaide, South Australia, Australia.
Martha MenberuDepartment of Surgery - Otolaryngology, Head and Neck Surgery, University of Adelaide, South Australia, Australia.
Erich VyskocilDepartment of Surgery - Otolaryngology, Head and Neck Surgery, University of Adelaide, South Australia, Australia.
Sarah VreugdeDepartment of Surgery - Otolaryngology, Head and Neck Surgery, University of Adelaide, South Australia, Australia.
Peter-John WormaldDepartment of Surgery - Otolaryngology, Head and Neck Surgery, University of Adelaide, South Australia, Australia.
University of South Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostoperative infections following endoscopic sinus surgery (ESS) impair wound healing and lead to poor outcomes. The aim of this study is to assess the effectiveness of Chitogel to reduce postoperative infections and restore a healthy microbiome following ESS.

methodsIn this double-blinded randomized control trial, 25 patients undergoing ESS were prospectively recruited. At the end of surgery, patients were randomized to receive Chitogel to one side of the sinuses (allowing the other side to serve as control). Patients underwent routine follow-up with nasoendoscopies performed at 2, 6, and 12 weeks postoperatively. Sinus ostial measurements, microbiology, and microbiome swabs from bilateral sides were collected intraoperatively and at 12 weeks postoperatively. Additional swabs were collected if infection was present.

resultsImproved endoscopic appearance of the sinuses (p = 0.03) and ostial patency were noted on the Chitogel side compared with control at 12 weeks (p < 0.001). A significant decrease in infections on the Chitogel side (12.0%) compared with control (52.0%) (p = 0.005) was evident. Following the use of Chitogel, there was a significant increase in the combined relative abundance of commensals Corynebacterium and Cutibacterium (Propionibacterium) from 30.15% at baseline to 46.62% at 12 weeks compared with control (47.18% to 40.79%) (p.adj = 0.01).

conclusionChitogel significantly improved both the nasoendoscopic appearance of the sinuses and sinus ostial patency at 12 weeks postoperatively. Chitogel used following ESS helps restore an improved microbiome resulting in an increase in the relative abundance of commensals Corynebacterium and Cutibacterium (Propionibacterium). A significant decrease in postoperative infections was noted following use of Chitogel.

Indexed as

MicrobiotaParanasal SinusesRhinitisSinusitisChronic DiseaseEndoscopyHumansPostoperative ComplicationsTreatment Outcomebacteriologychronic rhinosinusitisendoscopic sinus surgerypostoperativetopical therapy for chronic rhinosinusitis

Identifiers

PMID35319832
PMCPMC9790547
OpenAlexW4220667829

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.