Evidence map›Paper›PMID 35319825›Full record

ArticleJournal of tissue engineering and regenerative medicine2022

Selective kidney targeting increases the efficacy of mesenchymal stromal/stem cells for alleviation of murine stenotic-kidney senescence and damage.

Seo Rin Kim, Kai Jiang, Xiaojun Chen, Amrutesh S Puranik, Xiang-Yang Zhu, Amir Lerman, Tamara Tchkonia, James L Kirkland, Lilach O Lerman

Open access · greenAbstract read
In one paragraph

Article in Journal of tissue engineering and regenerative medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
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  5. Review
  6. Targeted therapeutic strategies for the kidney.Expert opinion on therapeutic targets · 2024
    Review
  7. Kidney Aging and Chronic Kidney Disease.International journal of molecular sciences · 2024
    Review
  8. Article
  9. Review
  10. Article
  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Seo Rin KimDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0003-3552-0519
Kai JiangDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.
Xiaojun ChenDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.
Amrutesh S PuranikDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.
Xiang-Yang ZhuDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.
Amir LermanDepartment of Cardiology, Mayo Clinic, Rochester, Minnesota, USA.
Tamara TchkoniaRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.
James L KirklandRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.
Lilach O LermanDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-3271-3887
Mayo Clinic · USMayo Clinic in Florida · USUniversity of Maryland, Baltimore · US

Funding

Targeting Cellular Senescence to Extend HealthspanP01AG062413 · NIA · MAYO CLINIC ROCHESTER · PI Diana Jurk · 2019 to 2026
$28.7M
Effect of Aging on Preadipocyte DifferentiationR37AG013925 · NIA · MAYO CLINIC ROCHESTER · PI KIRKLAND, JAMES L. · 2016 to 2025
$6.6M
Effect of Aging on Preadipocyte DifferentiationR01AG013925 · NIA · MAYO CLINIC ROCHESTER · PI KIRKLAND, JAMES L. · 1997 to 2012
$3.7M
Obesity-induced mesenchymal stem cell senescenceR01DK120292 · NIDDK · MAYO CLINIC ROCHESTER · PI LERMAN, LILACH O · 2019 to 2022
$2.6M
Quantitative magnetization transfer MRI for evaluation of renal fibrosisR01DK122734 · NIDDK · MAYO CLINIC ROCHESTER · PI LERMAN, LILACH O · 2020 to 2023
$2.2M
Mesenchymal stem cell senescence in diabetic nephropathy (K23 COVID Admin Supplement)K23DK109134 · NIDDK · MAYO CLINIC ROCHESTER · PI HICKSON, LATONYA J · 2016 to 2021
$1.0M
Noninvasive Evaluation of Renal Allograft Fibrosis by MRIR21AG062104 · NIA · MAYO CLINIC ROCHESTER · PI LERMAN, LILACH O · 2020 to 2021
$414k
NIA NIH HHS P01 AG062413NIA NIH HHS R01 AG013925NIA NIH HHS R21 AG062104NIA NIH HHS R37 AG013925NIDDK NIH HHS K23 DK109134NIDDK NIH HHS R01 DK120292NIDDK NIH HHS R01 DK122734
6 · The paper itself

Abstract

Chronic ischemia triggers senescence in renal tubules and at least partly mediates kidney dysfunction and damage through a p16

Indexed as

Mesenchymal Stem CellsRenal Artery ObstructionAnimalsCellular SenescenceCyclin-Dependent Kinase Inhibitor p16IschemiaKidneyMiceMice, TransgenicCyclin-Dependent Kinase Inhibitor p16cellular senescencekidney injury molecule-1mesenchymal stem cellsrenal artery stenosis

Identifiers

PMID35319825
PMCPMC9167737
OpenAlexW4220813160

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.