Evidence map›Paper›PMID 35319808›Full record

ArticleAngewandte Chemie (International ed. in English)2022

[FeFe]-Hydrogenase: Defined Lysate-Free Maturation Reveals a Key Role for Lipoyl-H-Protein in DTMA Ligand Biosynthesis.

Adrien Pagnier, Batuhan Balci, Eric M Shepard, Hao Yang, Douglas M Warui, Stella Impano, Squire J Booker, Brian M Hoffman, William E Broderick, Joan B Broderick

Open access · greenAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Biosynthesis of the Selenium-Substituted [FeFe]-Hydrogenases.Journal of the American Chemical Society · 2026
    Article
  3. Article
  4. [FeInorganic chemistry · 2025
    Article
  5. In vitro maturation of fully active [FeFe]-hydrogenase in a defined system including the iron carrier NfuA.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Hydrogen-Producing Catalysts Based on Ferredoxin Scaffolds.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Final Stages in the Biosynthesis of the [FeFe]-Hydrogenase Active Site.Angewandte Chemie (International ed. in English) · 2024
    Article
  11. Hybrids of [FeFe]- and [NiFe]-HOrganometallics · 2023
    Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Adrien PagnierDepartment of Chemistry & Biochemistry, Montana State University, Bozeman, MT 59717, USA.ORCID 0000-0002-1951-2415
Batuhan BalciDepartment of Chemistry & Biochemistry, Montana State University, Bozeman, MT 59717, USA.ORCID 0000-0002-1626-2705
Eric M ShepardDepartment of Chemistry & Biochemistry, Montana State University, Bozeman, MT 59717, USA.ORCID 0000-0002-4244-1045
Hao YangDepartment of Chemistry, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0001-7229-0957
Douglas M WaruiDepartment of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA.
Stella ImpanoDepartment of Chemistry & Biochemistry, Montana State University, Bozeman, MT 59717, USA.ORCID 0000-0002-8251-9441
Squire J BookerDepartment of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA.ORCID 0000-0002-7211-5937
Brian M HoffmanDepartment of Chemistry, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-3100-0746
William E BroderickDepartment of Chemistry & Biochemistry, Montana State University, Bozeman, MT 59717, USA.ORCID 0000-0001-5782-7322
Joan B BroderickDepartment of Chemistry & Biochemistry, Montana State University, Bozeman, MT 59717, USA.ORCID 0000-0001-7057-9124
Montana State University · USNorthwestern University · USPennsylvania State University · US

Funding

Research Core (Developmental Research Project Program)P20GM103474 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI Jeffrey Good · 2012 to 2026
$60.0M
Coboglobins-Cobalt-Substituted Hemoglobins and MyoglobinR01GM111097 · NIGMS · NORTHWESTERN UNIVERSITY · PI HOFFMAN, BRIAN M · 2014 to 2025
$6.7M
Ultra Performance Liquid Chromatography Tandem Mass Spectrometer for MetabolomicsS10OD028650 · OD · MONTANA STATE UNIVERSITY - BOZEMAN · PI BOTHNER, BRIAN P · 2020 to 2020
$599k
NIGMS NIH HHS P20 GM103474NIGMS NIH HHS R01 GM111097NIH HHS S10 OD028650
6 · The paper itself

Abstract

Maturation of [FeFe]-hydrogenase (HydA) involves synthesis of a CO, CN

Indexed as

HydrogenaseIron-Sulfur ProteinsElectron Spin Resonance SpectroscopyLigandsS-AdenosylmethionineHydrogenaseIron-Sulfur ProteinsLigandsS-AdenosylmethionineBiosynthesisDithiomethylamineGlycine Cleavage SystemHydrogenase MaturationLipoyl-H-Protein

Identifiers

PMID35319808
PMCPMC9117470
OpenAlexW4220998055

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.