ArticleeLife2022
Dendritic branch structure compartmentalizes voltage-dependent calcium influx in cortical layer 2/3 pyramidal cells.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Deep learning-assisted mapping of dendritic spines using sequential 2D two-photon calcium imaging.iScience · 2026Article
- Voltage dynamics of cortical dendrites in vivo.Nature neuroscience · 2026Article
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- Intrinsic neuronal diversity as a substrate for cortical area specialization in primate vision.Nature communications · 2026Article
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- A dendrite-resolved,bioRxiv : the preprint server for biology · 2026Article
- Spatial characterization of backpropagating action potential-evoked CaFrontiers in synaptic neuroscience · 2026Article
- Rules of life at the interface of calcium signaling and mechanobiology.APL bioengineering · 2025Review
- Article
- EPSILON: a method for pulse-chase labeling to probe synaptic AMPAR exocytosis during memory formation.Nature neuroscience · 2025Article
- Distinct synaptic plasticity rules operate across dendritic compartments in vivo during learning.Science (New York, N.Y.) · 2025Article
- Dendritic excitations govern back-propagation via a spike-rate accelerometer.Nature communications · 2025Article
- Photophysics-informed two-photon voltage imaging using FRET-opsin voltage indicators.Science advances · 2025Article
- Dendritic excitations govern back-propagation via a spike-rate accelerometer.bioRxiv : the preprint server for biology · 2024Article
- Photophysics-informed two-photon voltage imaging using FRET-opsin voltage indicators.bioRxiv : the preprint server for biology · 2024Article
- Synaptotagmin 7 Sculpts Short-Term Plasticity at a High Probability Synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Statistically unbiased prediction enables accurate denoising of voltage imaging data.Nature methods · 2023Article
- Asymmetric Voltage Attenuation in Dendrites Can Enable Hierarchical Heterosynaptic Plasticity.eNeuro · 2023Article
- Video-based pooled screening yields improved far-red genetically encoded voltage indicators.Nature methods · 2023Article
- Daily two-photon neuronal population imaging with targeted single-cell electrophysiology and subcellular imaging in auditory cortex of behaving mice.Frontiers in cellular neuroscience · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Back-propagating action potentials (bAPs) regulate synaptic plasticity by evoking voltage-dependent calcium influx throughout dendrites. Attenuation of bAP amplitude in distal dendritic compartments alters plasticity in a location-specific manner by reducing bAP-dependent calcium influx. However, it is not known if neurons exhibit branch-specific variability in bAP-dependent calcium signals, independent of distance-dependent attenuation. Here, we reveal that bAPs fail to evoke calcium influx through voltage-gated calcium channels (VGCCs) in a specific population of dendritic branches in mouse cortical layer 2/3 pyramidal cells, despite evoking substantial VGCC-mediated calcium influx in sister branches. These branches contain VGCCs and successfully propagate bAPs in the absence of synaptic input; nevertheless, they fail to exhibit bAP-evoked calcium influx due to a branch-specific reduction in bAP amplitude. We demonstrate that these branches have more elaborate branch structure compared to sister branches, which causes a local reduction in electrotonic impedance and bAP amplitude. Finally, we show that bAPs still amplify synaptically-mediated calcium influx in these branches because of differences in the voltage-dependence and kinetics of VGCCs and NMDA-type glutamate receptors. Branch-specific compartmentalization of bAP-dependent calcium signals may provide a mechanism for neurons to diversify synaptic tuning across the dendritic tree.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.