Evidence map›Paper›PMID 35319337›Full record

ArticleGut microbes

The development of live biotherapeutics against

Yongrong Zhang, Ashley Saint Fleur, Hanping Feng

Abstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Changes in the Epidemiology of Clostridioides difficile Infection.Infectious disease clinics of North America · 2025
    Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. The evolving landscape of live biotherapeutics in the treatment of Clostridioides difficile infection.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025
    Review
  9. Review
  10. Article
  11. Fungal and bacterial gut microbiota differ betweenMicrobiome research reports · 2024
    Article
  12. Article
  13. Microbiota of the gastrointestinal tract: Friend or foe?World journal of gastroenterology · 2023
    Review
  14. Unveiling the inhibition mechanism ofFrontiers in microbiology · 2023
    Article
  15. Gut Microbiota andInternational journal of molecular sciences · 2022
    Review
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yongrong ZhangDepartment of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, MD 21201, United States.
Ashley Saint FleurDepartment of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, MD 21201, United States.
Hanping FengDepartment of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, MD 21201, United States.

Funding

Shigella Live Vector-Based Multivalent VaccineU19AI109776 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI LEVINE, MYRON MAX · 2014 to 2018
$25.4M
Probiotic yeast secreting single-domain antibodies to prevent Clostridium difficile and Campylobacter jejuni diseaseU19AI142725 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI LEVINE, MYRON MAX · 2019 to 2023
$12.5M
A Novel Humanized Tetra-specific Antibody against Clostridium difficile InfectionR01AI132207 · NIAID · FZATA, INC. · PI FENG, HANPING, YANG, ZHIYONG · 2017 to 2022
$8.1M
Preventing norovirus and Clostridium difficile gastroenteritis by engineered probiotic yeast Saccharomyces boulardii secreting multi-specific single-domain antibodiesR01AI148357 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI FENG, HANPING, YUAN, LIJUAN · 2020 to 2024
$3.1M
Characterization of neutralizing antitoxins and epitopes in Clostridium difficile patientsR01AI148270 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI FENG, HANPING · 2020 to 2024
$1.9M
NIAID NIH HHS R01 AI132207NIAID NIH HHS R01 AI148270NIAID NIH HHS R01 AI148357NIAID NIH HHS U19 AI109776NIAID NIH HHS U19 AI142725
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Clostridioides difficileClostridium InfectionsGastrointestinal MicrobiomeAnti-Bacterial AgentsHumansVancomycinAnti-Bacterial AgentsVancomycinbiotherapeuticsClostridioides difficiledysbiosismicrobiotareconstitution

Identifiers

PMID35319337
PMCPMC8959509

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.