Evidence map›Paper›PMID 35319116›Full record

ArticleClinical endocrinology2022

Anti-Müllerian hormone concentration is associated with central adiposity and reproductive hormones in expectant fathers.

Narelle C Hadlow, Suzanne J Brown, Ee Mun Lim, David Prentice, Simone Pettigrew, Sophie L Cronin, Susan L Prescott, Desiree Silva, Bu B Yeap

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Narelle C HadlowMedical School, University of Western Australia, Perth, Western Australia, Australia.
Suzanne J BrownDepartment of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
Ee Mun LimMedical School, University of Western Australia, Perth, Western Australia, Australia.
David PrenticePerron Institute for Neurological and Translational Science, Perth, Western Australia, Australia.
Simone PettigrewGeorge Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.
Sophie L CroninMedical School, University of Western Australia, Perth, Western Australia, Australia.
Susan L PrescottMedical School, University of Western Australia, Perth, Western Australia, Australia.
Desiree SilvaMedical School, University of Western Australia, Perth, Western Australia, Australia.
Bu B YeapMedical School, University of Western Australia, Perth, Western Australia, Australia.ORCID 0000-0002-7612-5892
The University of Western Australia · AUEdith Cowan University · AUPerron Institute for Neurological and Translational Science · AUSir Charles Gairdner Hospital · AUThe Kids Research Institute Australia · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe role of the anti-Müllerian hormone (AMH) as an indicator of physical and reproductive health in men is unclear. We assessed the relationships between AMH and follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, and metabolic parameters, in a cohort of expectant fathers.

designORIGINS Project prospective cohort study.

settingCommunity-dwelling men.

participantsPartners of pregnant women attending antenatal appointments.

main outcome measuresSerum AMH, FSH, LH, testosterone, and metabolic parameters.

resultsIn 485 expectant fathers, median age 33 years, median AMH was 40 pmol/L (quartiles 29, 56). AMH was inversely correlated with FSH, age, and body mass index (BMI) (correlation coefficients: -.32, -.24, and -.17 respectively). The age association was nonlinear, with peak AMH between 20 and 30 years, a decline thereafter, and somewhat steady levels after 45 years. The inverse association of AMH with FSH was log-linear and independent of age and BMI (β: -.07, SE: 0.01, p < .001). AMH was inversely correlated with waist circumference and directly associated with sex hormone-binding globulin. Testosterone was moderately correlated with AMH (correlation coefficient: .09, β: .011, SE: 0.004, p = .014): this association was mediated by an inverse relationship with BMI (mediated proportion 0.49, p < .001).

conclusionsIn reproductively active men, lower AMH is a biomarker for advancing age, and for poorer metabolic and reproductive health. The inverse association between AMH and FSH is independent of age and BMI, whereas the association of AMH and testosterone is mediated via BMI. The utility of AMH to predict reproductive and cardiometabolic outcomes in men warrants further investigation.

Indexed as

Anti-Mullerian HormoneSex Hormone-Binding GlobulinAdiposityAdultBiomarkersFathersFemaleFollicle Stimulating HormoneHumansLuteinizing HormoneMaleObesityObesity, AbdominalPregnancyProspective StudiesTestosteroneAnti-Mullerian HormoneBiomarkersFollicle Stimulating HormoneLuteinizing HormoneSex Hormone-Binding GlobulinTestosteroneAMHBMIFSHmenORIGINS Projecttestosteronewaist circumference

Identifiers

PMID35319116
PMCPMC9790283
OpenAlexW4220877000

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.