ArticleAnaesthesia2022
Complications associated with paediatric airway management during the COVID-19 pandemic: an international, multicentre, observational study.
Article in Anaesthesia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06624696 (Inhaling Penehyclidine to Prevent Perioperative Respiratory Adverse Events in Children at Risk Undergoing Sevoflurane Anesthesia), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Inhaling Penehyclidine to Prevent Perioperative Respiratory Adverse Events in Children at Risk Undergoing Sevoflurane Anesthesia: a Double-blind, Randomized, Placebo-controlled Trial
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Postoperative outcomes of pediatric patients with perioperative COVID-19 infection: a systematic review and meta-analysis of observational studies.Journal of anesthesia · 2024Pooled it
- Timing of surgery after fever resolution in children with SARS-CoV-2: a prospective cohort study.BMJ open respiratory research · 2025Article
- Is General Anesthesia Safe for a Child with Acute Upper Respiratory Tract Infection? A Narrative Review.Pediatric reports · 2025Review
- Association of upper respiratory tract infection with perioperative respiratory adverse events in pediatric tonsillectomy patients : A propensity-matched cohort study.Italian journal of pediatrics · 2025Article
- Postoperative cardiopulmonary complications in children with preoperative Omicron SARS-CoV-2 variants infection: a single-center retrospective cohort study.BMC pediatrics · 2025Article
- Retrospective Cohort Study of Perioperative Complications in Symptomatic and Asymptomatic Children Testing SARS-CoV-2-Positive Within 21 Days Before Surgery.Paediatric anaesthesia · 2025Article
- Perioperative Respiratory-Adverse Events Following General Anesthesia Among Pediatric Patients After COVID-19.Journal of Korean medical science · 2023Article
- The influence of the COVID pandemic on the management of URTI in children.BJA education · 2023Review
- [Children need sustainability].Die Anaesthesiologie · 2023Review
- SARS-CoV-2 and paediatric anaesthesia: similar risk to classic viral upper respiratory tract infection, but still more to learn.Anaesthesia · 2023Article
- Management of the Normal and Difficult Pediatric Airway: Unique Challenges in the Time of COVID-19.Current surgery reports · 2023Review
- Anaesthesia in SARS-CoV-2 infected children - single-centre experience. A case-control study.Anaesthesiology intensive therapy · 2023Article
- A retrospective report on the preoperative mandatory SARS-COV-2 infection screening in a single pediatric center. Is it time to stop testing our patients?Revista do Colegio Brasileiro de Cirurgioes · 2023Article
- Postanesthesia complications in pediatric patients with previous SARS-CoV-2 infection: A cohort study.Paediatric anaesthesia · 2023Article
- SARS-CoV-2 airway reactivity in children: more of the same?Anaesthesia · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 8 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Respiratory adverse events in adults with COVID-19 undergoing general anaesthesia can be life-threatening. However, there remains a knowledge gap about respiratory adverse events in children with COVID-19. We created an international observational registry to collect airway management outcomes in children with COVID-19 who were having a general anaesthetic. We hypothesised that children with confirmed or suspected COVID-19 would experience more hypoxaemia and complications than those without. Between 3 April 2020 and 1 November 2020, 78 international centres participated. In phase 1, centres collected outcomes on all children (age ≤ 18 y) having a general anaesthetic for 2 consecutive weeks. In phase 2, centres recorded outcomes for children with test-confirmed or suspected COVID-19 (based on symptoms) having a general anaesthetic. We did not study children whose tracheas were already intubated. The primary outcome was the incidence of hypoxaemia during airway management. Secondary outcomes included: incidence of other complications; and first-pass success rate for tracheal intubation. In total, 7896 children were analysed (7567 COVID-19 negative and 329 confirmed or presumed COVID-19 positive). The incidence of hypoxaemia during airway management was greater in children who were COVID-19 positive (24 out of 329 (7%) vs. 214 out of 7567 (3%); OR 2.70 (95%CI 1.70-4.10)). Children who had symptoms of COVID-19 had a higher incidence of hypoxaemia compared with those who were asymptomatic (9 out of 51 (19%) vs. 14 out of 258 (5%), respectively; OR 3.7 (95%CI 1.5-9.1)). Children with confirmed or presumed COVID-19 have an increased risk of hypoxaemia during airway management in conjunction with general anaesthesia.
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Registered trials
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